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Analysis of chemical compounds and toxicological evaluation of Forsythia suspensa leaves tea

Food Science and Biotechnology 2021년 30권 2호 p.305 ~ 314
Wang Da-Hong, Wang Meng-Yang, Shen Wen-Hao, Yuan Jiang-Feng,
소속 상세정보
 ( Wang Da-Hong ) - Henan University of Science and Technology College of Food and Bioengineering
 ( Wang Meng-Yang ) - Henan University of Science and Technology College of Food and Bioengineering
 ( Shen Wen-Hao ) - Henan University of Science and Technology College of Food and Bioengineering
 ( Yuan Jiang-Feng ) - Henan University of Science and Technology College of Food and Bioengineering

Abstract


To determine the compositions of Forsythia suspensa leaves tea (FSLT) and its safety, the chemical compounds were analysed with some methods, and the toxicity was evaluated in Kunming mice and Wistar rats. The results showed that FSLT contained rich flavonoid, lignans, triperpene acids, amino acids, and mineral elements. In the acute toxicity study, none of the mice died, and no obvious poisoning symptoms were observed after 14 days in mice at the dose of 15 mg/g·body weight (bw) FSLT; in the sub-chronic toxicity, no abnormal or dead rat was found at the dose of 1, 3, and 10 mg/g·bw during 90 days feeding administration; there was no significant difference in bw and food consumption; no significant differences were found in each hematology and serum biochemistry parameter and organ/body weight ratio comparing with the control experimental group. The results revealed that the FSLT has low or no toxicity via oral administration. Therefore, FSLT is very suitable and safe to be used as a new resource food.

키워드

Forsythia suspensa leaves tea (FSLT); Chemical compound; Acute toxicity; Sub-chronic toxicity

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