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Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy

Food Science and Biotechnology 2021년 30권 3호 p.321 ~ 340
이용규, 이제형, 임창백,
소속 상세정보
이용규 ( Lee Yong-Kyu ) - Dongseo University Department of Food and Nutrition
이제형 ( Lee Je-Hyung ) - Dong-A University College of Medicine Department of Medicine
임창백 ( Lim Chang-Baek ) - Daewoo Pharmaceutical Co. Ltd.

Abstract


Since researchers began studying the mechanism of flavonoids’ anticancer activity, little attention has been focused on the modulation of redox state in cells as a potential chemotherapeutic strategy. However, recent studies have begun identifying that the anticancer effect of flavonoids occurs both in their antioxidative activity which scavenges ROS and their prooxidative activity which generates ROS. Against this backdrop, this study attempts to achieve a comprehensive analysis of the individual and separate study findings regarding flavonoids’ modulation of redox state in cancer cells. It focuses on the mechanism behind the anticancer effect, and mostly on the modulation of redox potential by flavonoids such as quercetin, hesperetin, apigenin, genistein, epigallocatechin-3-gallate (EGCG), luteolin and kaempferol in both in vitro and animal models. In addition, the clinical applications of and bioavailability of flavonoids were reviewed to help build a treatment strategy based on flavonoids’ prooxidative potential.

키워드

Flavonoid; Redox state modulation; Anticancer; Chemotherapeutic strategy

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