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Comparing the stability of retinol in liposomes with cholesterol, β-sitosterol, and stigmasterol

Food Science and Biotechnology 2021년 30권 3호 p.389 ~ 394
이동욱, 박혜원, 이승철,
소속 상세정보
이동욱 ( Lee Dong-Uk ) - Kyungnam University School of Bioconvergence
박혜원 ( Park Hye-Won ) - Kyungnam University School of Bioconvergence
이승철 ( Lee Seung-Cheol ) - Kyungnam University School of Bioconvergence

Abstract


In this study, cholesterol (CH), β-sitosterol (SI), and stigmasterol (ST) were explored to improve the stability of retinol in the liposome bilayer. Retinol was incorporated into liposomes composed of soybean-derived L-α-phosphatidylcholine (PC) and 10% sterol (w/w), which were prepared as multilamellar vesicles. Under all conditions, the efficiency of retinol incorporation into liposomes was higher than 99%, and the average particle size of liposomes was similar to that of PC alone. Liposomes were stored at 4 and 25 °C, with and without light, respectively, for 10 days. It was found that during the storage, CH and SI were effective in stabilizing the retinol in liposomes. These results indicate that an appropriate phytosterol could improve the stability of retinol in liposomes.

키워드

Retinol; Liposome; Phytosterol; Stability

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