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A facile macroporous resin-based method for separation of yellow and orange Monascus pigments

Food Science and Biotechnology 2021년 30권 4호 p.545 ~ 553
Chen Suo, Su Dong-Xiao, Gao Meng-Xiang, Zhang Jia-Lan, Liu Ying-Bao, Wu Qing-Hua, Yang Hua-Lin, Li Li,
소속 상세정보
 ( Chen Suo ) - Yangtze University College of Life Science
 ( Su Dong-Xiao ) - Guangzhou University School of Chemistry and Chemical Engineering
 ( Gao Meng-Xiang ) - Yangtze University College of Life Science
 ( Zhang Jia-Lan ) - Yangtze University College of Animal Science
 ( Liu Ying-Bao ) - Yangtze University College of Life Science
 ( Wu Qing-Hua ) - Yangtze University College of Life Science
 ( Yang Hua-Lin ) - Yangtze University College of Life Science
 ( Li Li ) - Yangtze University College of Life Science

Abstract


The yellow Monascus pigments (YMPs) named monascin and ankaflavin and the orange Monascus pigments (OMPs) named rubropunctatin and monascorubrin are two groups of bioactive components in a mixture state in the Monascus fermented products. In order to separate these two groups of bioactive pigments, a facile macroporous resin-based method was developed. The weak-polar resin CAD-40 was selected from the seven tested macroporous resins as it revealed better properties for the adsorption and desorption of the YMPs and OMPs. Then, CAD-40 resin was used for column-chromatographic separation. After eluted by 4 bed volumes of ethanol, the yellow group (monascin and ankaflavin) and the orange group (rubropunctatin and monascorubrin) were successfully separated and purified, with an increased content from 49.3% and 44.2% in the crude pigment extract to 85.2% and 83.0% in the final products, respectively. This method would be helpful for the large-scale separation and purification of Monascus pigment products with specific bioactivity.

키워드

Monascus pigments; Macroporous resin; Separation; Purification

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