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A Practical Utility and Benefit of Pharmacogenetic-based Antidepressant Treatment Strategy for Major Depressive Disorder Patients with Difficult-to-treat

Clinical Psychopharmacology and Neuroscience 2021년 19권 1호 p.160 ~ 165
이경호, 박원명, 이수정, Serretti Alessandro, 배지은,
소속 상세정보
이경호 ( Lee Kyung-Ho ) - Catholic University College of Medicine Department of Dermatology
박원명 ( Bahk Won-Myong ) - Catholic University College of Medicine Department of Psychiatry
이수정 ( Lee Soo-Jung ) - Catholic University College of Medicine Department of Psychiatry
 ( Serretti Alessandro ) - University of Bologna Department of Biomedical and NeuroMotor Sciences
배지은 ( Pae Chi-Un ) - Catholic University College of Medicine Department of Psychiatry

Abstract


Objective: We report the results of pharmacogenomics-based antidepressant treatment (PGXt) results in treating treatment-resistant major depressive disorder (TRD) patients in real practice.

Methods: Nine patients were prescribed Neuropharmagenⓡ for selection of antidepressants for individual patient and their clinical outcomes were followed.

Results: After treatment by PGXt results from current antidepressants, substantial reduction of depressive symptoms was observed at some point and maintained during observation period in six patients.

Conclusion: Our case series potentially shows the clinical utility and benefit of PGXt for treatment of TRD patients.

키워드

Treatment; Depressive disorder; Antidepressive agent; Treatment-resistance; Clinical outcome

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