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Delayed Onset of Manic Symptoms in a Patient with Influenza A (H1N1) after administration of Oseltamivir (Tamiflu): A Case Report

Clinical Psychopharmacology and Neuroscience 2021년 19권 1호 p.166 ~ 169
전민, 김주완, 강희주, 김선영, 이주연, 김성완, 신일선, 김재민,
소속 상세정보
전민 ( Jhon Min ) - Chonnam National University Medical School Department of Psychiatry
김주완 ( Kim Ju-Wan ) - Chonnam National University Medical School Department of Psychiatry
강희주 ( Kang Hee-Ju ) - Chonnam National University Medical School Department of Psychiatry
김선영 ( Kim Seon-Young ) - Chonnam National University Medical School Department of Psychiatry
이주연 ( Lee Ju-Yeon ) - Chonnam National University Medical School Department of Psychiatry
김성완 ( Kim Sung-Wan ) - Chonnam National University Medical School Department of Psychiatry
신일선 ( Shin Il-Seon ) - Chonnam National University Medical School Department of Psychiatry
김재민 ( Kim Jae-Min ) - Chonnam National University Medical School Department of Psychiatry

Abstract


Psychiatric side effects of oseltamivir can result in accident-proneness and suicide. Reportedly, such adverse psychiatric events are more common in children than in adults, but other risk factors are not known. We present a 13-year-old girl with influenza infection who developed manic symptoms after taking oseltamivir and receiving the human papillomavirus vaccination. While other research has found that psychiatric side effects associated with oseltamivir generally occur within 48 hours after beginning administration, in this case the manic symptoms developed on the fourth day after cessation of 5-day course of oseltamivir administration. Based on our review of this case, we recommend that clinicians should carry out vigilant monitoring of each patient’s mental state when the patient is young, has a family history of psychiatric disorder, has drug sensitivity and has received medical treatments such as vaccination before or after taking oseltamivir. In addition, as side effects of oseltamivir may occur more than 48 hours after administration, it will be necessary to observe patients for several days after the prescription of oseltamivir.

키워드

Oseltamivir; Influenza A virus; Papillomavirus vaccines; Drug-related side effects and adverse reactions

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