잠시만 기다려 주세요. 로딩중입니다.

Methyl Jasmonate: Behavioral and Molecular Implications in Neurological Disorders

Clinical Psychopharmacology and Neuroscience 2021년 19권 2호 p.220 ~ 232
Aluko Oritoke Modupe, Iroegbu Joy Dubem, Ijomone Omamuyovwi Meashack, Umukoro Solomon,
소속 상세정보
 ( Aluko Oritoke Modupe ) - Federal University of Technology Department of Physiology
 ( Iroegbu Joy Dubem ) - Federal University of Technology School of Health and Health Technology Neuro-Lab
 ( Ijomone Omamuyovwi Meashack ) - Federal University of Technology School of Health and Health Technology Neuro-Lab
 ( Umukoro Solomon ) - University of Ibadan Department of Pharmacology and Therapeutics

Abstract


Methyl jasmonate (MJ) is a derivative of the jasmonate family which is found in most tropical regions of the world and present in many fruits and vegetables such as grapevines, tomato, rice, and sugarcane. MJ is a cyclopentanone phytohormone that plays a vital role in defense against stress and pathogens in plants. This has led to its isolation from plants for studies in animals. Many of these studies have been carried out to evaluate its therapeutic effects on behavioral and neurochemical functions. It has however been proposed to have beneficial potential over a wide range of neurological disorders. Hence, this review aims to provide an overview of the neuroprotective properties of MJ and its probable mechanisms of ameliorating neurological disorders. The information used for this review was sourced from research articles and scientific databases using ‘methyl jasmonate’, ‘behavior’, ‘neuroprotection’, ‘neurodegenerative diseases’, and ‘mechanisms’ as search words. The review highlights its influences on behavioral patterns of anxiety, aggression, depression, memory, psychotic, and stress. The molecular mechanisms such as modulation of the antioxidant defense, inflammatory biomarkers, neurotransmitter regulation, and neuronal regeneration, underlying its actions in managing neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases are also discussed. This review, therefore, provides a detailed evaluation of methyl jasmonate as a potential neuroprotective compound with the ability to modify behavioral and molecular biomarkers underlying neurological disorders. Hence, MJ could be modeled as a guided treatment for the management of brain diseases.

키워드

Methyl jasmonate; Neuroprotection; Behavior; Neurodegenerative diseases; Depression; Anxiety

원문 및 링크아웃 정보

 

등재저널 정보