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Relationship between Handgrip Strength and Low-grade Inflammation in Older Adults with Depression

Clinical Psychopharmacology and Neuroscience 2021년 19권 4호 p.721 ~ 730
강귀영, 정영은, 장환, 김문두, 박원명,
소속 상세정보
강귀영 ( Kang Kwi-Young ) - Catholic University College of Medicine Department of Internal Medicine
정영은 ( Jung Young-Eun ) - Jeju National University College of Medicine Department of Psychiatry
장환 ( Jang Hwan ) - Catholic University College of Medicine Department of Internal Medicine
김문두 ( Kim Moon-Doo ) - Jeju National University College of Medicine Department of Psychiatry
박원명 ( Bahk Won-Myong ) - Catholic University College of Medicine Department of Psychiatry

Abstract


Objective: The relationship among physical functional decline, low-grade inflammation, and depression remains unclear. The aim of this study was to examine the association between hand grip strength (HGS) and high-sensitivity C-reactive protein (hs-CRP) in a large sample with depression.

Methods: This study used data obtained from a representative Korean sample of 9,402 people who participated in the seventh Korean National Health and Nutrition Examination Survey. Physical function was assessed using a digital grip strength dynamometer. Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as ≥ 3.0 mg/L.

Results: In older adults (≥ 60 years) with depression, 43.8% of those with high hs-CRP levels had low HGS, compared to 21.8% of those with hs-CRP levels < 3.0 mg/L (p = 0.002). Multivariate analysis revealed that, after adjustments for potentially confounding factors, high hs-CRP was independently associated with lower HGS (B = ?2.25; 95% confidence interval = ?4.49 to ?0.02) in older adults with depression, but not in younger or middle-aged adults with depression.

Conclusion: These findings suggest a significant correlation between physical functional decline and low-grade inflammation in older adults with depression.

키워드

Hand grip strength; C-reactive protein; PHQ-9; Depression; Inflammation; Older adults

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