잠시만 기다려 주세요. 로딩중입니다.

Clinical Characteristics of Patients with Schizophrenia Maintained without Antipsychotics: A Cross-sectional Survey of a Case Series

Clinical Psychopharmacology and Neuroscience 2021년 19권 4호 p.773 ~ 779
Tani Hideaki, Tomita Masayuki, Suzuki Takefumi, Mimura Masaru, Uchida Hiroyuki,
소속 상세정보
 ( Tani Hideaki ) - Keio University School of Medicine Department of Neuropsychiatry
 ( Tomita Masayuki ) - Ohizumi Hospital Department of Psychiatry
 ( Suzuki Takefumi ) - University of Yamanashi Yamanashi Faculty of Medicine Department of Neuropsychiatry
 ( Mimura Masaru ) - Keio University School of Medicine Department of Neuropsychiatry
 ( Uchida Hiroyuki ) - Keio University School of Medicine Department of Neuropsychiatry

Abstract


Objective: While antipsychotics are necessary for relapse prevention in the treatment of schizophrenia in general, some minority of patients may be maintained without continuous antipsychotic treatment. However, the characteristics of such patients are not well known and previous reports have not evaluated key elements such as physical comorbidities and functioning.

Methods: Among 635 patients with schizophrenia who participated in a 12-year follow-up, those who were maintained without antipsychotic treatment for at least one year after the study were investigated. The patients underwent comprehensive assessments, including Positive and Negative Syndrome Scale (PANSS) for psychopathology, Cumulative Illness Rating Scale for Geriatrics (CIRS-G) for physical comorbidities, and Functional Assessment for Comprehensive Treatment of Schizophrenia (FACT-Sz), Barthel Index, and EuroQoL five dimensions (EQ5D) for function.

Results: Six patients were included (mean ± standard deviation age, 66.8 ± 17.4 years; 4 inpatients). The four inpatients were old (77.8 ± 4.8 years) and chronically ill (duration of illness, 49.3 ± 12.5 years) with a high PANSS score (total score, 118.0 ± 9.8; negative syndrome subscale, 41.3 ± 6.9), low functioning (FACT-Sz, 9.8 ± 3.6; Barthel Index, 8.8 ± 9.6), and serious physical comorbidities (CIRS-G, 15.5 ± 1.1). By contrast, the two outpatients were relatively young (45.0 ± 12.0 years) and clinically in good condition (PANSS total score, 44.5 ± 0.5; Barthel Index, 100 for both; EQ5D, 0.85 ± 0.04).

Conclusion: Although the number is limited, two types of patients with schizophrenia were identified who were free from ongoing antipsychotic treatment; 1) older chronic inpatients with serious physical comorbidities, and 2) younger outpatients with milder impairments. Future explorations are needed to identify those who will be successfully withdrawn from continuous antipsychotic treatment.

키워드

Antipsychotics; Discontinuation; Maintenance; Schizophrenia

원문 및 링크아웃 정보

 

등재저널 정보