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Trazodone Add-on in COVID-19-related Selective Serotonin Reuptake Inhibitor-resistant Post-traumatic Stress Disorder in Healthcare Workers: Two Case Reports

Clinical Psychopharmacology and Neuroscience 2021년 19권 4호 p.780 ~ 785
De Berardis Domenico, Fornaro Michele, Ventriglio Antonio, Valchera Alessandro, Vellante Federica, Pettorruso Mauro, Martinotti Giovanni, Fraticelli Silvia, Di Giannantonio Massimo,
소속 상세정보
 ( De Berardis Domenico ) - Hospital G. Mazzini Department of Mental Health
 ( Fornaro Michele ) - Federico II University Department of Psychiatry
 ( Ventriglio Antonio ) - University of Foggia Department of Psychiatry
 ( Valchera Alessandro ) - Hermanas Hospitalarias Villa S. Giuseppe Clinic
 ( Vellante Federica ) - University G. D’Annunzio Department of Neurosciences and Imaging
 ( Pettorruso Mauro ) - University G. D’Annunzio Department of Neurosciences and Imaging
 ( Martinotti Giovanni ) - University G. D’Annunzio Department of Neurosciences and Imaging
 ( Fraticelli Silvia ) - University G. D’Annunzio Department of Neurosciences and Imaging
 ( Di Giannantonio Massimo ) - University G. D’Annunzio Department of Neurosciences and Imaging

Abstract


COVID-19 represents a significant stress factor for all people worldwide due to several factors, including quarantine, lockdowns, fear of contagion, deaths, and other traumatic events. However, the healthcare workers (HCWs) have paid the higher price of this pandemic in terms of fatalities, contagions, and psychological well-being. Studies suggest that this particular population is at increased risk of developing a severe post-traumatic stress disorder (PTSD). The early diagnosis and timely treatment of PTSD in HCWs may restore well-being and significantly impact health services functioning, reducing burnout, days spent far from work, disrupted personal and team empowerment, and worse job performances. In the present article, we reported on two cases of HCWs directly involved in the treatment of COVID-19 patients who showed selective serotonin reuptake inhibitor-resistant PTSD, which was successfully treated with extended-release trazodone TRZ Contramidⓡ add-on.

키워드

Healthcare workers; COVID-19; PTSD; Serotonin uptake inhibitors; Trazodone; Add-on

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