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Acute Hepatitis Due to Agomelatine Use in Elderly Women with Depression: Case Series

Clinical Psychopharmacology and Neuroscience 2021년 19권 4호 p.789 ~ 792
Chang Cheng-Chen, Chen Yen-Jen, Chen Yu-An, Liao Yi-Cheng,
소속 상세정보
 ( Chang Cheng-Chen ) - Changhua Christian Hospital Department of Psychiatry
 ( Chen Yen-Jen ) - Changhua Christian Hospital Department of Psychiatry
 ( Chen Yu-An ) - Changhua Christian Hospital Department of Psychiatry
 ( Liao Yi-Cheng ) - Changhua Christian Hospital Department of Psychiatry

Abstract


Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.

키워드

Agomelatine; Acute hepatitis; Major depression

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