잠시만 기다려 주세요. 로딩중입니다.

에페리손을 포함한 중추성 근이완제의 약물이상반응 특성

Characteristics of Adverse Drug Reactions of Central Muscle Relaxants Including Eperisone: Analysis of KAERS Data

약물역학위해관리학회지 2020년 12권 2호 p.79 ~ 84
박가윤, 손재은, 문미라, 이주연, 강혜련, 강동윤,
소속 상세정보
박가윤 ( Park Ga-Yoon ) - Seoul National University Hospital Drug Safety Monitoring Center
손재은 ( Sohn Jae-Eun ) - Seoul National University Hospital Drug Safety Monitoring Center
문미라 ( Moon Mi-Ra ) - Seoul National University Hospital Drug Safety Monitoring Center
이주연 ( Lee Ju-Yeun ) - Seoul National University College of Pharmacy
강혜련 ( Kang Hye-Ryun ) - Seoul National University Hospital Drug Safety Monitoring Center
강동윤 ( Kang Dong-Yoon ) - Seoul National University Hospital Drug Safety Monitoring Center

Abstract


Objective: Eperisone is the most widely prescribed muscle relaxant in Korea. However, few studies have investigated the adverse drug reactions (ADRs) of eperisone in the Korean population. A study is needed to analyze the ADR characteristics of eperisone in Koreans, especially the risk of anaphylaxis compared to other spasmolytic agents.

Methods: The individual safety case report (ISCR) of 1989 to 2015 from the Korea Institute of Drug Safety and Risk Management (KIDS) have been analyzed. Frequent ADRs of eperisone were listed by using World Health Organization Adverse Reaction Terminology classification. The proportional reporting ratio (PRR) has been calculated to estimate the risk of anaphylaxis caused by eperisone compared to other central muscle relaxants.

Results: 9,036 cases (1.1%) were related to central muscle relaxants among a total of 860,224 ISCRs from 1989 to 2015. Eperisone was the first place as 3,030 cases (33.5%). The symptoms of eperisone-induced ADRs were mostly similar with those of other central muscle relaxants. However, the anaphylaxis, which is a serious ADR that could be life-threatening, was significantly more reported in ADRs related to eperisone than those related to other central muscle relaxants (PRR = 4.80, 95% confidence interval: 2.73-8.41, p < 0.001).

Conclusion: Eperisone is highly related to drug-induced anaphylaxis compared to other central muscle relaxants.

키워드

Central muscle relaxants; Drug-related side effects and adverse reactions; Drug hypersensitivity; Anaphylaxis

원문 및 링크아웃 정보

등재저널 정보