잠시만 기다려 주세요. 로딩중입니다.

Comparison of inflammation-based prognostic scores as predictors of survival outcomes in patients with germ cell tumors

Investigative and Clinical Urology 2021년 62권 1호 p.47 ~ 55
Yoshinaga Kasumi, Sadahira Takuya, Maruyama Yuki, Mitsui Yosuke, Iwata Takehiro, Wada Koichiro, Araki Motoo, Watanabe Toyohiko, Nasu Yasutomo,
소속 상세정보
 ( Yoshinaga Kasumi ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Sadahira Takuya ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Maruyama Yuki ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Mitsui Yosuke ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Iwata Takehiro ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Wada Koichiro ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Araki Motoo ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Watanabe Toyohiko ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology
 ( Nasu Yasutomo ) - Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Urology

Abstract


Purpose: The aim of this study was to compare the prognostic value of pretreatment inflammation-based scoring systems in terms of overall survival (OS) and progression-free survival (PFS) in patients with germ cell tumors (GCTs) receiving bleomycin, etoposide, and cisplatin (BEP) chemotherapy.

Materials and Methods: We evaluated 63 patients with GCTs retrospectively. The Glasgow prognostic score (GPS), neutrophil-to-lymphocyte ratio, prognostic index, platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), systemic immune-inflammation index, and albumin-to-globulin ratio (AGR) were measured in all patients before chemotherapy. To assess the predictive ability of each scoring system, areas under the receiver operating characteristic curve were calculated, and multivariate analysis was performed to identify associations between the predictive scores and OS.

Results: Of all the inflammation-based scoring systems, the GPS had the greatest area under the curve (0.847) for predicting OS, followed by the PNI (0.829) and AGR (0.810). Kaplan?Meier analyses revealed that the GPS, PNI, and AGR were significantly associated with OS, whereas the GPS, PLR, and PNI were significantly associated with PFS. In the multivariate analysis, the GPS was an independent predictor of OS and PFS.

Conclusions: We demonstrated that the GPS was the most valuable biomarker of OS and PFS in patients with GCTs.

키워드

Germ cell tumor; Glasgow prognostic score; Prognostic nutritional index

원문 및 링크아웃 정보

등재저널 정보