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Effects of Motor Skill Learning and Treadmill Exercise on Motor Performance and Synaptic Plasticity in Harmaline Induced Cerebellar Injury Model of Rat

김기도, 민경옥, 김경윤, 심기철, 남기원, 구자풍, 박주현, 문옥곤, 유성훈, 김계엽,
소속 상세정보
김기도 ( Kim Gi-Do ) - Dongshin University
민경옥 ( Min Kyung-Ok ) - Yongin University
김경윤 ( Kim Kyung-Yoon ) - Dongshin University
심기철 ( Sim Ki-Cheol ) - Dongshin University
남기원 ( Nam Ki-Won ) - Dongshin University
구자풍 ( Koo Ja-Pung ) - Sarang Hospital
박주현 ( Park Joo-Hyun ) - Sarang Hospital
문옥곤 ( Moon Ok-Kon ) - Kunjang College
유성훈 ( Yu Seong-Hun ) - Cheomdan Hospital
김계엽 ( Kim Gye-Yeop ) - Dongshin University

Abstract


This study is intended to examine the motor skill learning and treadmill exercise on motor performance and synaptic plasticity in the cerebellar injured rats by harmaline. Experiment groups were divided into four groups and assigned 15 rats to each group. GroupⅠ was a normal control group(induced by saline); GroupⅡ was a experimental control group(cerebellar injured by harmaline); GroupⅢ was a group of motor skill learning after cerebellar injured by harmaline; GroupⅣ was a group of treadmill exercise after cerebellar injured by harmaline. In motor performance test, the outcome of groupⅡ was significantly lower than the groupⅢ, Ⅳ(especially groupⅢ)(p<.001). In histological finding, the experimental groups were destroy of dendrities and nucleus of cerebellar neurons. GroupⅢ, Ⅳ were decreased in degeneration of cerebellar neurons(especially groupⅢ). In immunohistochemistric response of synaptophysin in cerebellar cortex, experimental groups were decreased than groupⅠ. GroupⅢ’s expression of synaptophysin was more increased than groupⅡ, Ⅳ. In electron microscopy finding, the experimental groups were degenerated of Purkinje cell. These result suggest that improved motor performance by motor skill learning after harmaline induced is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity.

키워드

Cerebellar; Harmaline; Motor Performance; Motor Skill Learning; Synaptic Plasticity

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