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Effects of EA Application to GV20 and LI4 on BAX and NF-kB Expression of the SD-Rat’s Hippocampus with Global Ischemia

최정현, 김성원, 이재갑, 김미희, 김지성, 최유림, 윤영대, 김지혁, 김용성, 김년준, 이주환, 이상빈,
소속 상세정보
최정현 ( Choi Jung-Hyun ) - Namseoul University
김성원 ( Kim Sung-Won ) - Dongnam Health University
이재갑 ( Lee Jae-Gap ) - Hallym University Sacred Heart Hospital
김미희 ( Kim Min-Hee ) - Hallym University Sacred Heart Hospital
김지성 ( Kim Ji-Sung ) - Suwon Womens College
최유림 ( Choi Yoo-Rim ) - Daegu Science College
윤영대 ( Yun Young-Dae ) - Yonsei Semirae Hospital
김지혁 ( Kim Chi-Hyok ) - Kyungnam College of Technology
김용성 ( Kim Yong-Seong ) - St. Vincent’s Hospital
김년준 ( Kim Nyeon-Jun ) - Pohang College
이주환 ( Lee Ju-Hwan ) - Armed Forces Capital Hospital
이상빈 ( Lee Sang-Bin ) - Namseoul University

Abstract


This study aims to reveal how EA affects BAX and NF-kB involved in cell deaths from global ischemia, and to do this, observes the changes of BAX and NF-kB caused by EA application after transient global ischemia. The experimental method is to give rise to global ischemia and apply EA to 27 SD rats with the particulars of being six-week-old, male, around-300 gram-weighing, and adapted to laboratory environment for more than a week, and divide them into three groups, that is, GV20 EA group(n=9), L14 EA group(n=9), no-treatment GI group(n=9), and then observe their changes of BAX and NF-kB at the time lapse of 6 hours, 9 hours and 12 hours after ischemia, using western blotting. The numerical decrease of BAX expression at the time lapse of 9 hours after EA application, though not statistically significant, was observed in GV20 EA group and L14 EA group, and the NF-kB expression appeared statistically significant decrease in GV20 EA group and L14 EA group, but the expression was higher in the group with EA application. Therefore, EA application at the early phase of global ischemia is considered to affect BAX and NF-kB and play a positive role in decreasing apoptosis and cell deaths by inflammation.

키워드

Electro-Acupuncture; GV20; LI4; BAX; NF-kB

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