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The Effects of tDCS and Montoya Stair Task on Sensorimotor Recovery and GFAP Expression in MCAo induced Stroke Rat Model

심기철, 김기도, 김경윤, 안호정, 이준희, Min Kyoung-Ok, 김계엽,
소속 상세정보
심기철 ( Sim Ki-Cheol ) - Dongshin University
김기도 ( Kim Gi-Do ) - International University of Korea
김경윤 ( Kim Kyung-Yoon ) - Dongshin University
안호정 ( An Ho-Jung ) - Daewon University College
이준희 ( Lee Joon-Hee ) - Daebul University
 ( Min Kyoung-Ok ) - Yongin University
김계엽 ( Kim Gye-Yeop ) - Dongshin University

Abstract


This study is intended to examine the tDCS and Montoya stair task(MST) on sensorimotor recovery and glial scar expression in MCAo induced stroke model of rat. To achieve this goal, this study selected 80 SD rats of 8 weeks. The experiment groups were divided them into four groups, and assigned 20 rats to each group. GroupⅠwas a experimental control group; GroupⅡ was a tDCS application group after MCAo; GroupⅢ was a MST application group after MCAo; GroupⅣ was a tDCS and MST application group after MCAo. In each group, neurological function test measurement, motor behavior test, montoya stair task test, immunohistochemistric finding of GFAP expression finding were analyzed. In motor behavior test, the outcome of groupⅠ was significantly difference than the other group, especially from 14days. In montoya stair task test, the outcome of groupⅠ was significantly lower than the other group especially, groupⅡ were significantly different on 14days and group Ⅳ was most significantly difference than the other group. In immunohistochemistric finding, groupⅡ, Ⅲ, Ⅳ were decrease GFAP expression on depend on time stream. These results throughout the MCAo due to focal ischemic brain injury rat model four weeks tDCS and MST was applied, when the neurobehavioural, upper extremity function and ability, histopathologic data suggest that sensorimotor function recovery and a positive influence on glial scar decrease and confirmed that.

키워드

MCAo; tDCS; Montoya Stair Task; GFAPThis study is intended to examine the tDCS and Montoya stair

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