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돼지에서 생체 분해 금속성 전달체를 활용한 구제역 백신의 적용 연구

Application of biodegradable metal based drug delivery carrier on Foot and Mouth Disease vaccination in pigs

한국가축위생학회지 2020년 43권 3호 p.129 ~ 137
조아라, 오상익, 최창용, 정영훈, 도윤정, 김수희, 추현욱, 구종수, 정우진, 조성윤, 류재규,
소속 상세정보
조아라 ( Cho A-Ra ) - RDA National Institute of Animal Science Division of Animal Diseases & Health
오상익 ( Oh Sang-Ik ) - RDA National Institute of Animal Science Division of Animal Diseases & Health
최창용 ( Choe Chang-Yong ) - RDA National Institute of Animal Science Division of Animal Diseases & Health
정영훈 ( Jung Young-Hun ) - RDA National Institute of Animal Science Division of Animal Diseases & Health
도윤정 ( Do Yoon-Jung ) - RDA National Institute of Animal Science Division of Animal Diseases & Health
김수희 ( Kim Su-Hee ) - RDA National Institute of Animal Science Division of Animal Diseases & Health
추현욱 ( Choo Hyun-Wook ) - LABnPEOPLE Co. Ltd.
구종수 ( Gu Jong-Su ) - LABnPEOPLE Co. Ltd.
정우진 ( Chung Woo-Jin ) - LABnPEOPLE Co. Ltd.
조성윤 ( Cho Sung-Youn ) - LABnPEOPLE Co. Ltd.
류재규 ( Yoo Jae-Gyu ) - RDA National Institute of Animal Science Division of Animal Diseases & Health

Abstract


In this study, we applied biodegradable drug delivery carries (BDDC) for food-and-mouth (FMD) vaccination. After FMD vaccination using BDDC, we estimated the percentage inhibition (PI) of antibody, decomposed patterns, and histopathologic features of BDDC. PI of antibody was higher than 50 at two weeks after injection and sustained positive PI until 10 weeks after injection. BBDC injection group showed significantly an increased pattern of blood monocyte at two and three weeks after injection. According to the Micro CT, micro-cracks were observed at two weeks after injection and the morphology of BDDC was lost at four weeks after injection. For histopathological examination, acute inflammation with neutrophil infiltration and micro-metallic residues were observed around BDDC until four weeks after injection and inflammatory responses gradually decreased at 10 weeks. Based on our experiment, BDDC is considered as an alternative way to vaccine injection for veterinary applications. Our study can be used as basic data for the drug delivery system using biodegradable metals in the future.

키워드

Biodegradable metal; Vaccine injection; Animal application

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