잠시만 기다려 주세요. 로딩중입니다.

Subacute Oral Toxicity Evaluation of Freeze-Dried Powder of Locusta migratoria

한국축산식품학회지 2020년 40권 5호 p.795 ~ 812
곽규원, 김선영, 안규섭, 김용순, 박관호, 김은선, 황재삼, 김미애, 류현열, 윤형주,
소속 상세정보
곽규원 ( Kwak Kyu-Won ) - Rural Development Administration National Institute of Agricultural Sciences Department of Agricultural Biology
김선영 ( Kim Sun-Young ) - Rural Development Administration National Institute of Agricultural Sciences Department of Agricultural Biology
안규섭 ( An Kyu-Sup ) - Korea Conformity Laboratories Bioconvergence Technology Laboratory
김용순 ( Kim Yong-Soon ) - Rural Development Administration National Academy of Agricultural Science Department of Agricultural Biology
박관호 ( Park Kwan-Ho ) - Rural Development Administration National Institute of Agricultural Sciences Department of Agricultural Biology
김은선 ( Kim Eun-Sun ) - Rural Development Administration National Institute of Agricultural Sciences Department of Agricultural Biology
황재삼 ( Hwang Jae-Sam ) - Rural Development Administration National Institute of Agricultural Sciences Department of Agricultural Biology
김미애 ( Kim Mi-Ae ) - Rural Development Administration National Institute of Agricultural Sciences Department of Agricultural Biology
류현열 ( Ryu Hyeon-Yeol ) - Korea Conformity Laboratories Bioconvergence Technology Laboratory
윤형주 ( Yoon Hyung-Joo ) - Rural Development Administration National Institute of Agricultural Sciences Department of Agricultural Biology

Abstract


Novel food sources have enormous potential as nutritional supplements. For instance, edible insects are considered as an alternative food source due to their higher protein content; moreover, they are economically efficient reproducers and have high in nutritional value. In this study, we investigated the toxicity of the freeze-dried powder of Locusta migratoria (fdLM), known to contain rich proteins as well as fatty acids. The objective of the present study was to evaluate the subacute toxicity of fdLM in male and female Sprague-Dawley (SD) rats. The SD rats were divided into four groups based on the dosage of fdLM administered: dosage of 0 (vehicle control), 750, 1,500, and 3,000 mg/kg/day were administered for 28 days. Toxicological assessments including observations on food consumption, body and organ weights, clinical signs, mortality, ophthalmologic tests, urinalyses, hematologic tests, clinical chemistry tests, gross findings, and histopathology tests were performed. Clinical signs, urinalyses, hematology, serum biochemistry tests, and organ weight examinations revealed no fdLM-related toxicity. The no-observed-adverse-effect level for fdLM was higher than 3,000 mg/kg/day in rats of both sexes; therefore, fdLM, in conclusion, can be considered safe as an edible alternative human and animal food source material.

키워드

subacute toxicity; Locusta migratoria; freeze-dried powder; edible insects; Sprague-Dawley rats

원문 및 링크아웃 정보

등재저널 정보