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Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues

박소연, 정경아, 조은헤, 정혜원,
소속 상세정보
박소연 ( Park So-Yun ) - Ewha Womans University College of Medicine Department of Obstetrics and Gynecology
정경아 ( Jeong Kyung-Ah ) - Ewha Womans University College of Medicine Department of Obstetrics and Gynecology
조은헤 ( Cho Eun-Hye ) - Ewha Womans University College of Medicine Department of Obstetrics and Gynecology
정혜원 ( Chung Hye-Won ) - Ewha Womans University College of Medicine Department of Obstetrics and Gynecology

Abstract


In Korean women, a westernized lifestyle is associated with an increased risk of breast cancer. Fertility preservation has become an increasingly important issue for women with breast cancer, in accordance with substantial improvements in survival rate after cancer treatment. The methods of controlled ovarian hyperstimulation (COH) for fertility preservation in breast cancer patients have been modified to include aromatase inhibitors to reduce the potential harm associated with increased estradiol levels. Random-start COH and dual ovarian stimulation are feasible options to reduce the total duration of fertility preservation treatment and to efficiently collect oocytes or embryos. Using a gonadotropin-releasing hormone agonist as a trigger may improve cycle outcomes in breast cancer patients undergoing COH for fertility preservation. In young breast cancer patients with BRCA mutations, especially BRCA1 mutations, the possibility of diminished ovarian reserve may be considered, although further studies are necessary. Herein, we review the current literature on the practical issues surrounding COH for fertility preservation in women with breast cancer.

키워드

Breast neoplasms; Fertility preservation; Ovarian hyperstimulation

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