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Gender Differences in Korean Patients with Obstructive Sleep Apnea

Sleep Medicine Research 2020년 11권 2호 p.121 ~ 128
변소영, 최수정, 조현진, 황윤하, 조재욱, 주은연,
소속 상세정보
변소영 ( Pyun So-Young ) - LTG Neuro Medical Center Department of Neurology
최수정 ( Choi Su-Jung ) - Sungkyunkwan University Graduate School of Clinical Nursing Science Department of Nursing
조현진 ( Jo Hyun-Jin ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurology
황윤하 ( Hwang Yoon-Ha ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurology
조재욱 ( Cho Jae-Wook ) - Pusan National University Yangsan Hospital Department of Neurology
주은연 ( Joo Eun-Yeon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Neurology

Abstract


Background and Objective: Our objective in this study was to investigate gender-specific differences in demographic factors, clinical presenting symptoms, medical comorbidities, and sleep-related parameters in patients newly diagnosed with obstructive sleep apnea (OSA).

Methods: We enrolled patients who were more than 30 years old, had undergone overnight polysomnography, and had filled out the questionnaires, including demographics, medical comorbidities, and sleep-related symptoms.

Results: From December 2014 to August 2017, 1224 patients (female, n = 277, 22.6%) were newly diagnosed with OSA. Female patients were significantly older than males (59.62 years vs. 52.75 years, p < 0.001). Alcohol consumption and current smoking were more common in males (p < 0.001). Non-specific symptoms of OSA, such as insomnia-related symptoms, loss of energy, and subjective poor sleep, were observed more frequently in females. Females reported more depressive moods (Beck Depression Inventory-II 15.58) than males did (12.17). Males complained about OSA-specific symptoms, such as snoring, witnessed apnea, and daytime sleepiness, more frequently than females did. The mean apnea-hypopnea index (AHI) was much lower in females (26.25 /h vs. 33.36 /h), but AHI during rapid eye movement sleep was similar for the two groups (33.55 /h vs. 32.76 /h). Sleep latency was longer (15.45 min vs. 10.11 min) and spontaneous arousal index (4.48 /h vs. 3.48 /h) was more frequent in females.

Conclusions: Females have a different OSA phenotype from males in terms of demographics, clinical manifestations, and sleep parameters of polysomnography. Thus, clinicians should comprehend the different clinical phenotype of female OSA and detect earlier unrecognized OSA in females.

키워드

Obstructive sleep apnea; Sex; Sleep initiation and maintenance disorders; Polysomnography

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