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REvisiting Lipids in REtinal Diseases: A Focused Review on Age-related Macular Degeneration and Diabetic Retinopathy

Journal of Lipid and Atherosclerosis 2020년 9권 3호 p.406 ~ 418
박수진, 박동호,
소속 상세정보
박수진 ( Park Su-Jin ) - Kyungpook National University School of Medicine Kyungpook National University Hospital Department of Ophthalmology
박동호 ( Park Dong-Ho ) - Kyungpook National University School of Medicine Kyungpook National University Hospital Department of Ophthalmology

Abstract


Dyslipidemia refers to an abnormal amount of lipid in the blood, and the total cholesterol level is defined as the sum of high-density lipoprotein cholesterol, low-density lipoprotein (LDL) cholesterol, and very-LDL cholesterol concentrations. In Korea, the westernization of lifestyle habits in recent years has caused an increase in the incidence of dyslipidemia, which is an important risk factor of cardiovascular disease (CVD). Several studies have been conducted on how dyslipidemia affects not only CVD, but also chorioretinal diseases such as age-related macular degeneration (AMD) and diabetic retinopathy. Recently, a pathological model of AMD was proposed under the assumption that AMD proceeds through a mechanism similar to that of atherosclerotic CVD. However, controversy remains regarding the relationship between chorioretinal diseases and lipid levels in the blood, and the effects of lipid-lowering agents. Herein, we summarize the role of lipids in chorioretinal diseases. In addition, the effects of lipid-lowering agents on the prevention and progression of chorioretinal diseases are presented.

키워드

Age-related macular degeneration; Cholesterol; Diabetic retinopathy; Lipids; Hypolipidemic agents

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