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The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis

Journal of Lipid and Atherosclerosis 2020년 9권 3호 p.419 ~ 434
이한터, 오상현, Ro Du-Hyun, 유혜린, 권유욱,
소속 상세정보
이한터 ( Lee Han-Teo ) - Seoul National University Graduate School of Convergence Science and Technology Department of Molecular Medicine and Biopharmaceutical Sciences
오상현 ( Oh Sang-Hyeon ) - Seoul National University Graduate School of Convergence Science and Technology Department of Molecular Medicine and Biopharmaceutical Sciences
 ( Ro Du-Hyun ) - Seoul National University Graduate School of Convergence Science and Technology Department of Molecular Medicine and Biopharmaceutical Sciences
유혜린 ( Yoo Hye-Rin ) - Seoul National University Graduate School of Convergence Science and Technology Department of Molecular Medicine and Biopharmaceutical Sciences
권유욱 ( Kwon Yoo-Wook ) - Seoul National University College of Medicine Department of Medicine

Abstract


Atherosclerosis, which is the most common chronic disease of the coronary artery, constitutes a vascular pathology induced by inflammation and plaque accumulation within arterial vessel walls. Both DNA methylation and histone modifications are epigenetic changes relevant for atherosclerosis. Recent studies have shown that the DNA methylation and histone modification systems are closely interrelated and mechanically dependent on each other. Herein, we explore the functional linkage between these systems, with a particular emphasis on several recent findings suggesting that histone acetylation can help in targeting DNA methylation and that DNA methylation may control gene expression during atherosclerosis.

키워드

DNA methylation; Histones; Acetylation; Atherosclerosis

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