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Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass

Annals of Pediatric Endocrinology & Metabolism 2020년 25권 3호 p.174 ~ 181
Siviero-Miachon Adriana Aparecida, Spinola-Castro Angela Maria, Andreoni Solange, de Martino Lee Maria Lucia, Calixto Antonio Ramos, Geloneze Bruno, Guerra-Junior Gil,
소속 상세정보
 ( Siviero-Miachon Adriana Aparecida ) - Federal University of Sao Paulo - UNIFESP/EPM Division of Pediatric Endocrinology
 ( Spinola-Castro Angela Maria ) - Federal University of Sao Paulo - UNIFESP/EPM Division of Pediatric Endocrinology
 ( Andreoni Solange ) - UNIFESP/EPM Department of Preventive Medicine
 ( de Martino Lee Maria Lucia ) - Hospital Santa Marcelina/TUCCA Division of Pediatric Oncology
 ( Calixto Antonio Ramos ) - State University of Campinas - UNICAMP Faculty of Medical Sciences
 ( Geloneze Bruno ) - State University of Campinas - UNICAMP Faculty of Medical Sciences
 ( Guerra-Junior Gil ) - UNICAMP Faculty of Medical Sciences Division of Pediatric Endocrinology

Abstract


Purpose: This cross-sectional study evaluated the relationship between adipokines (leptin, adiponectin, visfatin, and resistin) and adiposity indexes regarding sex and cranial radiotherapy exposure among young acute lymphocytic leukemia survivors.

Methods: A multivariate analysis of covariance (MANCOVA) was used to evaluate the joint effect of sex, cranial radiotherapy, and body mass index (BMI) z-score (model 1) or fat mass index (FMI) (model 2) on adipokines.

Results: This study included 55 survivors of childhood acute lymphocytic leukemia between 15 and 23 years of age from both sexes (56.4% female); 43.6% of the sample had undergone cranial radiotherapy (18?24 Gy). The BMI z-score, the FMI, and sex (P<0.050 for all) influenced at least one adipokine, while cranial radiotherapy exposure was marginal in model 2. Parameter estimates from the MANCOVA's final model showed that the BMI z-score (β=-0.437, P=0.010) and the FMI (β=-0.209, P=0.004) negatively influenced adiponectin, while the FMI positively affected resistin (β=0.142, P=0.020). The relationship between leptin, visfatin, and the adiposity ndexes could not be established. In model 1, females presented with increased adiponectin (β=-1.014, P=0.011) and resistin (β=-1.067, P=0.002) levels; in model 2, female sex positively affected adiponectin (β=-1.515, P=0.001) and marginally influenced resistin (β=-0.707, P=0.054) levels. Cranial radiotherapy negatively determined visfatin levels in both final models (P<0.050).

Conclusions: Changes in body fat may be associated with adipose tissue dysfunction and should be carefully evaluated in survivors of acute lymphocytic leukemia, considering both sex and cranial radiotherapy exposure, to treat disorders that may possibly aggravate their risk for early cardiovascular disease.

키워드

Precursor cell lymphoblastic leukemia-lymphoma; Radiotherapy; Complications; Body weight; Adipokines; Adipose tissue

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