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A case of primary hyperparathyroidism due to an intrathymic ectopic parathyroid adenoma in a 15-year-old boy

Annals of Pediatric Endocrinology & Metabolism 2020년 25권 3호 p.187 ~ 191
서영석, 송경철, 최한샘, 서정환, 권아름, 채현욱, 김호성,
소속 상세정보
서영석 ( Seo Young-Seok ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics
송경철 ( Song Kyung-Chul ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics
최한샘 ( Choi Han-Saem ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics
서정환 ( Suh Jung-Hwan ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics
권아름 ( Kwon Ah-Reum ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics
채현욱 ( Chae Hyun-Wook ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics
김호성 ( Kim Ho-Seong ) - Yonsei University College of Medicine Severance Children’s Hospital Department of Pediatrics

Abstract


Hypercalcemia due to primary hyperparathyroidism (PHPT) is uncommon in children. PHPT is typically caused by a single parathyroid adenoma. Ectopic parathyroid adenomas account for 6%?16% of all parathyroid adenomas and are rare in children but should be considered in cases that present with hypercalcemia. We report the case of a 15-year-old boy with PHPT due to an intrathymic ectopic parathyroid adenoma. Neck ultrasonography and Tc-99m-sestamibi (MIBI) scanning with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed ectopic parathyroid adenoma in the thymus. Video-assisted thoracoscopic surgery was performed to remove the ectopic parathyroid adenoma. Pathology showed intrathymic ectopic parathyroid adenoma. After surgery, the patient’s serum calcium level immediately normalized. Intact parathyroid hormone (iPTH) and alkaline phosphatase levels returned to normal ranges within 3 months. Delayed diagnosis of PHPT can cause end-organ damage; a timely diagnosis is especially critical to preserve bone and renal function. If ectopic parathyroid adenomas are well localized in preoperative imaging evaluation and intraoperative iPTH level decreases after resection, ectopic parathyroidectomy without bilateral neck exploration may be performed to avoid unnecessary morbidity.

키워드

Primary hyperparathyroidism; Hypercalcemia; Ectopic parathyroid gland; Parathyroid adenoma; Child

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