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Medical Lasers; Engineering, Basic Research, and Clinical Application

장소영, Carpena Nathaniel T., 강봉진, 이민영,
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장소영 ( Chang So-Young ) - Dankook University Beckman Laser Institute Korea
 ( Carpena Nathaniel T. ) - Dankook University College of Medicine Department of Otolaryngology-Head and Neck Surgery
강봉진 ( Kang Bong-Jin ) - Dankook University College of Medicine Department of Anesthesiology and Pain Medicine
이민영 ( Lee Min-Young ) - Dankook University College of Medicine Department of Otolaryngology-Head and Neck Surgery

Abstract


The use of stem cell therapy to treat various diseases has become a promising approach. The ability of stem cells to self-renew and differentiate can contribute significantly to the success of regenerative medical treatments. In line with these expectations, there is a great need for an efficient research methodology to differentiate stem cells into their specific targets. Photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), is a relatively non-invasive technique that has a therapeutic effect on damaged tissue or cells. Recent advances in adapting PBM to stem cell therapy showed that stem cells and progenitor cells respond favorably to light. PBM stimulates different types of stem cells to enhance their migration, proliferation, and differentiation in vitro and in vivo. This review summarizes the effects of PBM on targeted differentiation across multiple stem cell lineages. The analytical expertise gained can help better understand the current state and the latest findings in PBM and stem cell therapy.

키워드

Stem cell differentiation; Photobiomodulation; Low-level laser therapy; Regenerative application; Therapeutic effect

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