잠시만 기다려 주세요. 로딩중입니다.

Testosterone Deficiency and Risk of Cognitive Disorders in Aging Males

The World Journal of Men′s Health 2021년 39권 1호 p.9 ~ 18
Corona Giovanni, Guaraldi Federica, Rastrelli Giulia, Sforza Alessandra, Maggi Mario,
소속 상세정보
 ( Corona Giovanni ) - Maggiore-Bellaria Hospital Azienda Usl Medical Department Endocrinology Unit
 ( Guaraldi Federica ) - IRCCS Institute of Neurological Science of Bologna Pituitary Unit
 ( Rastrelli Giulia ) - University of Florence Department of Experimental, Clinical and Biomedical Sciences
 ( Sforza Alessandra ) - Italy Maggiore-Bellaria Hospital Azienda Usl Medical Department
 ( Maggi Mario ) - University of Florence Department of Experimental, Clinical and Biomedical Sciences

Abstract


Cognitive impairment and dementia are predicted to undergo a dramatic increase in the following years with more than 131.5 million people being affected by 2030. Although vascular diseases play the most important role in the pathogenesis of memory impairment in aging men, some pre-clinical and clinical evidence has suggested a possible contribution of the age-dependent reduction of testosterone (T). In this paper we have summarized and discussed all the information derived from available animal and experimental studies. In addition, we meta-analyzed data rising from all randomized placebo controlled trials (RCTs) published so far. Only limited preclinical and clinical evidence can support a possible contribution of T in the pathogenesis of the age-dependent impairment of cognitive functions. In addition, our meta-analysis did not support the use of T replacement therapy for the improvement of several cognitive domains analyzed including attention/working memory, executive function, language, verbal memory, visual memory, visuomotor ability, and visuospatial ability. However, it is important to recognize that the vast majority of available RCTs included mixed populations of subjects with eugonadism and hypogonadism preventing any final conclusion being drawn on these issues.

키워드

Aging; Cognitive impairment; Dementia; Hypogonadism; Testosterone

원문 및 링크아웃 정보

등재저널 정보

SCI(E)
KCI
KoreaMed