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Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia

The World Journal of Men′s Health 2021년 39권 2호 p.346 ~ 351
Alahmar Ahmed T., Calogero Aldo E., Sengupta Pallav, Dutta Sulagna,
소속 상세정보
 ( Alahmar Ahmed T. ) - University of Sumer College of Science
 ( Calogero Aldo E. ) - University of Catania University Teaching Hospital Policlinico-Vittorio Emanuele
 ( Sengupta Pallav ) - MAHSA University Faculty of Medicine, Bioscience and Nursing
 ( Dutta Sulagna ) - MAHSA University Faculty of Dentistry, Bioscience and Nursing

Abstract


Purpose: Oxidative stress and sperm DNA fragmentation (SDF) are potential contributing factors for idiopathic male infertility. Coenzyme Q10 (CoQ10) have been reported to be effective in the treatment of idiopathic male infertility, in general, owing to its antioxidant properties. Thus, the present study intends to investigate the effects of CoQ10 therapy on semen parameters, oxidative stress markers and SDF in infertile men, specifically with idiopathic oligoasthenozoospermia (OA).

Materials and Methods: In this case-control study, sixty-five infertile patients with idiopathic OA and forty fertile men (control) were included. All participants underwent semen analysis based on the World Health Organization guidelines (5th edition, 2010). Patients received CoQ10 at the dose of 200 mg/d orally for three months. Seminal plasma CoQ10, total antioxidant capacity (TAC), total reactive oxygen species (ROS), glutathione peroxidase (GPx), and SDF levels were measured in controls (baseline) and infertile patients pre- and post-CoQ10 treatment.

Results: CoQ10 treatment for three months significantly improved sperm concentration (p<0.05), progressive motility (p<0.05), total motility (p<0.01), seminal fluid CoQ10 concentration (p<0.001), TAC (p<0.001), and GPx (p<0.001) levels in infertile men with OA. Further, ROS level (p<0.05) and SDF percentage (p<0.001) were reduced in OA patients as compared to the baseline. CoQ10 levels also correlated positively with sperm concentration (r=0.48, p=0.01) and total motility (r=0.59, p=0.003) while a negative correlation was recorded between SDF and sperm motility (r=?0.54, p=0.006).

Conclusions: CoQ10 supplementation for three months could improve semen parameters, oxidative stress markers and reduce SDF in infertile men with idiopathic OA.

키워드

Coenzyme Q10; DNA fragmentation; Male infertility; Oxidative stress; Sperm

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