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Assessing the short-term effects of radiotherapy on the shear modulus of the common carotid artery as a new biomarker of radiation-induced atherosclerosis

Ultrasonography 2022년 41권 1호 p.114 ~ 123
Mohammadkarim Alireza, Mokhtari-Dizaji Manijhe, Kazemian Ali, Saberi Hazhir, Yazdi Niloofar Ayoobi, Esfehani Mahbod,
소속 상세정보
 ( Mohammadkarim Alireza ) - Tarbiat Modares University Faculty of Medical Sciences Department of Medical Physics
 ( Mokhtari-Dizaji Manijhe ) - Tarbiat Modares University Faculty of Medical Sciences Department of Medical Physics
 ( Kazemian Ali ) - Tehran University of Medical Sciences Cancer Institute Radiation Oncology Research Center
 ( Saberi Hazhir ) - Tehran University of Medical Sciences Imam Khomeini Hospital Department of Radiology
 ( Yazdi Niloofar Ayoobi ) - Tehran University of Medical Sciences Imam Khomeini Hospital Department of Radiology
 ( Esfehani Mahbod ) - Tehran University of Medical Sciences Cancer Institute of Iran Department of Radiation Oncology

Abstract


Purpose: The purpose of this study was to investigate the incidence of short-term atherosclerosis in the common carotid arteries following radiotherapy.

Methods: The mean radiation dose to the arteries was 49.30±15.83 Gy. A computational ultrasound method was introduced to investigate the elastic modulus. Ultrasonography was performed 2-3 cm inferior to the bifurcation region before and after radiotherapy, and sequential images were extracted from a video of each artery. Instantaneous movement of the arterial wall in the radial and longitudinal directions was extracted by implementing the maximum gradient and block matching algorithms, respectively.

Results: There was a significant change in systolic blood pressure after radiotherapy (P=0.008). Irradiated arteries had significantly smaller systolic and end-diastolic diameters than non-irradiated arteries (P<0.001). The shear modulus was significantly different between irradiated and non-irradiated arteries (3.10±2.03 kPa vs. 1.38±0.98 kPa, P<0.001). The shear and Young moduli of radiation-induced arteries were 2.25±1.50 and 1.57±0.59 times higher than those of the pre-irradiation arteries.

Conclusion: The arterial shear modulus can be considered as a new biomarker of radiation-induced atherosclerosis in the common carotid artery.

키워드

Ultrasonography; Carotid artery; Image processing; External radiotherapy; Shear modulus

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