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Assessment of thyroid-specific quality of life in patients with benign symptomatic thyroid nodules treated with radiofrequency or ethanol ablation: a prospective multicenter study

Ultrasonography 2022년 41권 1호 p.204 ~ 211
정소영, 하은주, 백정환, 김태영, 이유미, 이정현, 이정훈,
소속 상세정보
정소영 ( Jeong So-Yeong ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
하은주 ( Ha Eun-Ju ) - Ajou University School of Medicine Department of Radiology
백정환 ( Baek Jung-Hwan ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
김태영 ( Kim Tae-Yong ) - University of Ulsan College of Medicine Asan Medical Center Department of Internal Medicine
이유미 ( Lee Yu-Mi ) - University of Ulsan College of Medicine Asan Medical Center Department of Surgery
이정현 ( Lee Jeong-Hyun ) - University of Ulsan College of Medicine Asan Medical Center Department of Radiology
이정훈 ( Lee Jeong-Hun ) - Ajou University School of Medicine Department of Surgery

Abstract


Purpose: Radiofrequency ablation (RFA) and ethanol ablation (EA) are effective and safe for benign symptomatic thyroid nodules (BSTNs). However, relatively little is known about the effects of these procedures on patients’ quality of life (QoL). This prospective, multicenter study evaluated the effects of RFA and EA on changes in thyroid-specific QoL in patients with BSTNs and assessed the volume reduction and safety of these procedures.

Methods: Eighty-six consecutive patients with 86 BSTNs were prospectively included from two medical centers. RFA was performed for 55 BSTNs with solidity ≥50% and EA was performed for 31 BSTNs with solidity <50%. QoL was evaluated using an 11-scale, multiple-choice thyroid-specific QoL questionnaire. Nodule characteristics and QoL were evaluated at diagnosis and 1, 6, and 12 months after treatment. Overall QoL was rated from 0 (good) to 4 (poor).

Results: The mean longest size and volume of the index nodule were 4.2±1.5 cm and 21.6±22.1 mL, respectively. Patients received 1.1 treatments on average (range, 1 to 2). Significant post-treatment volume reductions were noted; however, the EA group showed a higher volume reduction than the RFA group at 1 (78.7%-16.1% vs. 49.1%-15.8%), 6 (86.3%-21.7% vs. 73.0%-14.5%), and 12 (90.9%-14.9% vs. 80.3%-12.4%) months. The score for each scale of the QoL questionnaire improved significantly during follow-up (all P<0.001). Overall QoL improved significantly, from 1.7±0.9 at diagnosis to 0.6±0.7 at the 12-month follow-up (P<0.001). There were no major complications.

Conclusion: Both RFA and EA are safe and effective in reducing nodule volume and improving thyroid-specific QoL in patients with BSTNs.

키워드

Radiofrequency ablation; Ethanol; Quality of life; Thyroid nodule

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