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Harnessing genome-wide association studies to minimize adverse radiation-induced side effects

Radiation Oncology Journal 2020년 38권 4호 p.226 ~ 235
Benitez Cecil M., Knox Susan J.,
소속 상세정보
 ( Benitez Cecil M. ) - Stanford University School of Medicine Department of Radiation Oncology
 ( Knox Susan J. ) - Stanford University School of Medicine Department of Radiation Oncology

Abstract


Radiotherapy is used as definitive treatment in approximately two-thirds of all cancers. However, like any treatment, radiation has significant acute and long-term side effects including secondary malignancies. Even when similar radiation parameters are used, 5%?10% of patients will experience adverse radiation side effects. Genomic susceptibility is thought to be responsible for approximately 40% of the clinical variability observed. In the era of precision medicine, the link between genetic susceptibility and radiation-induced side effects is further strengthening. Genome-wide association studies (GWAS) have begun to identify single-nucleotide polymorphisms (SNPs) attributed to overall and tissue-specific toxicity following radiation for treatment of breast cancer, prostate cancer, and other cancers. Here, we review the use of GWAS in identifying polymorphisms that are predictive of acute and long-term radiation-induced side effects with a focus on chest, pelvic, and head-and-neck irradiation. Integration of GWAS with “omic” data, patient characteristics, and clinical correlates into predictive models could decrease radiation-induced side effects while increasing therapeutic efficacy.

키워드

Radiogenomics; Radiation-induced side effects; Genome-wide association study (GWAS); Normal tissue toxicity; Radiotherapy

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