잠시만 기다려 주세요. 로딩중입니다.

쇼그렌 및 비쇼그렌증후군 환자에서 안구표면염색점수와 혈중 비타민 D 농도의 상관관계 비교

Correlation between Ocular Surface Staining Score and Serum Vitamin D in Sjogren’s and Non-Sjogren’s Syndrome

검안 및 콘택트렌즈학회지 2021년 20권 1호 p.32 ~ 38
공예슬, 강규동, 김현승, 황형빈,
소속 상세정보
공예슬 ( Gong Ye-Seul ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Ophthalmology
강규동 ( Kang Kui-Dong ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Ophthalmology
김현승 ( Kim Hyun-Seung ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Ophthalmology
황형빈 ( Hwang Hyung-Bin ) - Catholic University College of Medicine Incheon St. Mary’s Hospital Department of Ophthalmology

Abstract


Purpose: To analyze the correlation between the ocular surface staining score (OSS) and serum vitamin D level for patients of Sjogren's syndrome (group A) and non-Sjogren's syndrome (group B) with dry eye symptoms.

Methods: In this observational cross-sectional study, The Schirmer I test, OSS, tear film break-up time and serum vitamin D level were measured in 65 eyes of 65 adults complaining of dry eye. Among 65 people, 35 people in group A and 30 people in group B. The Student’s t-test was used for analyzing the ocular surface staining respectively, in group A and group B patients. Pearson’s correlation was used to analyze the correlations of OSS with serum vitamin D level.

Results: The serum vitamin D level (rho = -0.245, p = 0.049) was negatively correlated with OSSs. Especially, the serum vitamin D level (rho = -0.440, p = 0.008) was significantly negatively correlated with OSSs in Sjogren's syndrome patients even more than total patient group.

Conclusions: This suggests that the OSS is highly related to immunological factors such as vitamin D in dry eyes due to an underlying immunological disease. Finding the exact relationship between the inducer of dry eye and the degree of dry eye and clarifying the correlation seems to play an important role in the direction of treatment for dry eye.

키워드

Dry eye syndrome; Keratoconjunctivitis sicca; Ocular staining score; Sjogren’s syndrome; Vitamin D

원문 및 링크아웃 정보

등재저널 정보