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A comparison of post vaccination hepatitis B surface antibody level on the large and appropriate for gestational age infants

Clinical and Experimental Vaccine Research 2021년 10권 1호 p.47 ~ 51
Esteghamati Abdoulreza, Sayyahfar Shirin, Ghaemi Hossein, Joulani Mohammadamin, Moradi Yousef, Talebi Atefeh,
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 ( Esteghamati Abdoulreza ) - Iran University of Medical Sciences Institute of Immunology and Infectious Diseases Research Center of Pediatric Infectious Diseases
 ( Sayyahfar Shirin ) - Iran University of Medical Sciences Institute of Immunology and Infectious Diseases Research Center of Pediatric Infectious Diseases
 ( Ghaemi Hossein ) - Iran University of Medical Sciences
 ( Joulani Mohammadamin ) - Iran University of Medical Sciences School of Medicine Student Research Committee
 ( Moradi Yousef ) - Kurdistan University of Medical Sciences Research Institute for Health Development Social Determinants of Health Research Center
 ( Talebi Atefeh ) - Iran University of Medical Sciences Colorectal Research Center

Abstract


Purpose: The aim of this study was to compare the hepatitis B surface antibody (HBs Ab) titer 1 month after the 4th dose of hepatitis B vaccine administration on the large and appropriate for gestational age infants.

Materials and Methods: This cross-sectional study was conducted on 7-month-old cases (n=132) divided into two groups of 2?4 kg (group 1: appropriate for gestational age, 63 cases) and >4 kg (group 2: large for gestational age, 69 cases), whom were vaccinated with a four-dose schedule of hepatitis B vaccine in 2016, Tehran, Iran.

Results: Mean birth weight of the groups was 2.98±0.528 and 4.19±0.190 kg, respectively. Hepatitis B surface antigen and hepatitis B core antibody were negative in all cases. HBs Ab level in group 1 and 2 was 13,701.00±11,744.439 and 8,997.15±2,827.191, respectively (95% confidence interval of difference, ?7,607.44 to ?1,800.25). There was a significant difference between the two groups in antibody titration and antibody logarithm level (p=0.002, p=0.0001).

Conclusion: Birth weight may affect the response to the hepatitis B virus vaccine administration.

키워드

Birth weight; Hepatitis B surface antibody; Hepatitis B; Hepatitis B virus; Hepatitis B vaccines; Large for gestational age; Vaccines

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