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Discrepancy between the Actual Clinical Status of Patients with Hepatocellular Carcinoma and Expectations from Hepatocellular Carcinoma Surveillance: a Single-Center Study

대한간암학회지 2019년 19권 1호 p.30 ~ 37
김낙민, 도영석, 장지웅, 김석환, 은혁수, 전재범, 김새희, 백일현, 정성희,
소속 상세정보
김낙민 ( Kim Nak-Min ) - Eulji University School of Medicine Department of Internal Medicine
도영석 ( Doh Young-Seok ) - Eulji University School of Medicine Department of Internal Medicine
장지웅 ( Jang Ji-Woong ) - Eulji University School of Medicine Department of Internal Medicine
김석환 ( Kim Seok-Hwan ) - Catholic University College of Medicine Daejeon St. Mary’s Hospital Department of Internal Medicine
은혁수 ( Eun Hyuk-Soo ) - Chungnam National University College of Medicine Department of Internal Medicine
전재범 ( Jun Jae-Bum ) - Eulji University School of Medicine Department of Internal Medicine
김새희 ( Kim Sae-Hee ) - Eulji University School of Medicine Department of Internal Medicine
백일현 ( Baek Il-Hyun ) - Eulji University School of Medicine Department of Internal Medicine
정성희 ( Jung Sung-Hee ) - Eulji University School of Medicine Department of Internal Medicine

Abstract


Background/Aims: The National Liver Cancer Screening Program (NLCSP) has been implemented for the past 15 years in Korea. However, the actual clinical experience in Korea is inconsistent with the expectations of the hepatocellular carcinoma (HCC) surveillance program. To evaluate the actual clinical situation of HCC diagnoses, we investigated disease severity in patients with HCC and the diagnostic environment.

Methods: From January 2011 to December 2015, all patients who were diagnosed with HCC in a single secondary hospital in Daejeon city were retrospectively enrolled in this study. Severity of HCC was evaluated according to the Barcelona Clinic Liver Cancer (BCLC) staging system.

Results: Over the course of 5 years, 298 participants were enrolled. The mean age of participants was 64.0 years. Positive hepatitis B surface antigen was confirmed in 134 patients (45.0%), 35 patients (11.7%) tested positive for anti-hepatitis C virus antibody, and 93 patients (32.2%) had more than 40 g/day of alcohol consumption. The proportions of patients according to BCLC stages were as follows: BCLC-0, 28 patients (9.4%); BCLC-A, 42 patients (14.1%); BCLC-B, 26 patients (8.7%); BCLC-C, 134 patients (45.0%); and BCLC-D, 68 patients (22.8%). The diagnostic environments were as follows: 19 patients were in the NLCSP group (6.4%), 114 in the group with presenting signs (38.3%), 110 in the regular outpatient care group (36.9%), and 55 patients in the incidental diagnosis group (18.5%).

Conclusions: Most patients (67.8%) had advanced stage HCC at diagnosis, and curative treatment was not indicated due to the severity disease. Thus, the actual situation is far worse than the theoretical expectation of HCC surveillance, suggesting that many high-risk patients for HCC are missed in surveillance.

키워드

Hepatocellular carcinoma; Surveillance; Mass screening; Chronic Hepatitis B; Epidemiology

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