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Liver Transplantation after Successful Downstaging with Hepatic Arterial Infusion Chemotherapy in a Patient with Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

대한간암학회지 2019년 19권 1호 p.64 ~ 68
남희철, 성필수, 천호종, 김동구, 장정원, 최종영, 윤승규,
소속 상세정보
남희철 ( Nam Hee-Chul ) - Catholic University College of Medicine Department of Internal Medicine
성필수 ( Sung Pil-Soo ) - Catholic University College of Medicine Department of Internal Medicine
천호종 ( Chun Ho-Jong ) - Catholic University College of Medicine Department of Radiology
김동구 ( Kim Dong-Goo ) - Catholic University College of Medicine Department of Surgery
장정원 ( Jang Jeong-Won ) - Catholic University College of Medicine Department of Internal Medicine
최종영 ( Choi Jong-Young ) - Catholic University College of Medicine Department of Internal Medicine
윤승규 ( Yoon Seung-Kew ) - Catholic University College of Medicine Department of Internal Medicine

Abstract


Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The majority of patients with HCC are diagnosed at advanced disease stages with vascular invasion, where curative approaches are often not feasible. Currently, sorafenib is the only available standard therapy for HCC with portal vein tumor thrombosis (PVTT). However, in many cases, sorafenib therapy fails to achieve satisfactory results in clinical practice. We present a case of advanced HCC with PVTT that was treated with hepatic arterial infusion chemotherapy (HAIC) followed by liver transplantation. Three cycles of HAIC treatment resulted in necrotic changes in most of the tumors, and PVTT was reduced to an extent at which liver transplantation was possible. Further studies are required to determine the treatment strategies for advanced HCC with PVTT that can improve prognosis.

키워드

Hepatocellular carcinoma; Venous thrombosis

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