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Early Experience of Oncolytic Virus Injection Combined with Sorafenib in a Patient with Advanced Hepatocellular Carcinoma and Portal Vein Thrombosis

대한간암학회지 2020년 20권 2호 p.177 ~ 182
조현호, 전성준, 유정주, 이민희, 김상균, 김영석,
소속 상세정보
조현호 ( Jo Hyun-Ho ) - Soonchunhyang University Bucheon Hospital Department of Internal Medicine
전성준 ( Chun Seong-Joon ) - Soonchunhyang University Bucheon Hospital Department of Internal Medicine
유정주 ( Yoo Jeong-Ju ) - Soonchunhyang University Bucheon Hospital Department of Internal Medicine
이민희 ( Lee Min-Hee ) - Soonchunhyang University Bucheon Hospital Department of Radiology
김상균 ( Kim Sang-Gyune ) - Soonchunhyang University Bucheon Hospital Department of Internal Medicine
김영석 ( Kim Young-Seok ) - Soonchunhyang University Bucheon Hospital Department of Internal Medicine

Abstract


JX-594 is a modified oncolytic poxvirus designed to selectively replicate in and destroy cancer cells. In a pilot study, JX-594 injection followed by sorafenib was well-tolerated in three patients and associated with objective tumor responses. In this study, we report a case in which a patient with advanced hepatocellular carcinoma and portal vein thrombosis was treated with a combination of JX-594 and sorafenib.

키워드

Oncolytic virus; JX-594; Sorafenib

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