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Immune landscape and biomarkers for immuno-oncology in colorectal cancers

Journal of Pathology and Translational Medicine 2020년 54권 5호 p.351 ~ 360
배정모, 유승연, 김정호, 강경훈,
소속 상세정보
배정모 ( Bae Jeong-Mo ) - Seoul National University College of Medicine Department of Pathology
유승연 ( Yoo Seung-Yeon ) - Seoul National University College of Medicine Department of Pathology
김정호 ( Kim Jung-Ho ) - Seoul National University College of Medicine Department of Pathology
강경훈 ( Kang Gyeong-Hoon ) - Seoul National University College of Medicine Department of Pathology

Abstract


Recent advances in immuno-oncology have increased understanding of the tumor immune microenvironment (TIME), and clinical trials for immune checkpoint inhibitor treatment have shown remission and/or durable response in certain proportions of patients stratified by predictive biomarkers. The TIME in colorectal cancer (CRC) was initially evaluated several decades ago. The prognostic value of the immune response to tumors, including tumor-infiltrating lymphocytes, peritumoral lymphoid reaction, and Crohn’s-like lymphoid reaction, has been well demonstrated. In this review, we describe the chronology of TIME research and review the up-to-date high-dimensional TIME landscape of CRC. We also summarize the clinical relevance of several biomarkers associated with immunotherapy in CRC, such as microsatellite instability, tumor mutational burden, POLE/POLD mutation, consensus molecular subtype, and programmed death-ligand 1 expression.

키워드

Colorectal neoplasms; Tumor immune microenvironment; Immunotherapy; Microsatellite instability

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