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A retrospective cytohistological correlation of fine-needle aspiration cytology with classification by the Milan System for Reporting Salivary Gland Cytopathology

Journal of Pathology and Translational Medicine 2020년 54권 5호 p.419 ~ 425
박지현, 차윤진, 서자영, 임재열, 홍순원,
소속 상세정보
박지현 ( Park Ji-Hyun ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Pathology
차윤진 ( Cha Yoon-Jin ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Pathology
서자영 ( Seo Ja-Yeong ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Pathology
임재열 ( Lim Jae-Yol ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Otorhinolaryngology
홍순원 ( Hong Soon-Won ) - Yonsei University College of Medicine Gangnam Severance Hospital Department of Pathology

Abstract


Background: Before publication of the new classification system named the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) in 2018, there was no standard classification for salivary gland lesions obtained by fine-needle aspiration (FNA). We therefore aimed to evaluate the diagnostic utility of this system by retrospectively reviewing FNA samples using the MSRSGC and to determine their risk of developing into neoplasms and becoming malignant.

Methods: Retrospective slide review and classification of salivary gland FNAs obtained over a 6-year period (2013?2018) at a single center were performed by two pathologists. The risks of neoplasm and malignancy for each category also were calculated.

Results: This study surveyed 374 FNAs (371 patients) performed over a six-year period and selected 148 cases that included documented surgical follow-up (39.6%). Among the surgically treated cases, the distributions of FNA categories were as follows: non-diagnostic (ND; 16.9%), non-neoplastic (NN; 2.7%), atypia of undetermined significance (AUS; 3.4%), benign (BN; 54.7%), salivary gland neoplasm of uncertain malignant potential (SUMP; 10.1%), suspicious for malignancy (SM; 6.8%), and malignant (M; 5.4%). The risk of malignancy (ROM) was 24.0% for ND, 0% for NN, 40.0% for AUS, 2.5% for BN, 46.7% for SUMP, 100% for SM, and 87.5% for M. The overall diagnostic accuracy was 95.9% (142/148 cases).

Conclusions: The newly proposed MSRSGC appears to be a reliable system for classification of salivary gland lesions according to the associated ROM.

키워드

Salivary gland; Fine-needle aspiration; The Milan System for Reporting Salivary Gland Cytopathology; Risk of malignancy

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