잠시만 기다려 주세요. 로딩중입니다.

Histologically confirmed distant metastatic urothelial carcinoma from the urinary bladder: a retrospective review of one institution’s 20-year experience

Journal of Pathology and Translational Medicine 2021년 55권 2호 p.94 ~ 101
Yoo Young-Eun, 이정혜, 박혜성, 조민선, 성순희, 박상희, 최은오,
소속 상세정보
 ( Yoo Young-Eun ) - Ewha Womans University College of Medicine Department of Pathology
이정혜 ( Lee Jung-Hye ) - Ewha Womans University College of Medicine Department of Pathology
박혜성 ( Park Heae-Surng ) - Ewha Womans University College of Medicine Department of Pathology
조민선 ( Cho Min-Sun ) - Ewha Womans University College of Medicine Department of Pathology
성순희 ( Sung Sun-Hee ) - Ewha Womans University College of Medicine Department of Pathology
박상희 ( Park Sang-Hui ) - Ewha Womans University College of Medicine Department of Pathology
최은오 ( Choi Eun-O ) - Ewha Womans University College of Medicine Department of Pathology

Abstract


Background: Urothelial carcinoma (UC) accounts for roughly 90% of bladder cancer, and has a high propensity for diverse differentiation. Recently, certain histologic variants of UC have been recognized to be associated with unfavorable clinical outcomes. Several UC studies have also suggested that tumor budding is a poor prognostic marker. Distant metastasis of UC after radical cystectomy is not uncommon. However, these metastatic lesions are not routinely confirmed with histology.

Methods: We investigated the histopathologic features of 13 cases of UC with biopsy-proven distant metastases, with a special emphasis on histologic variants and tumor budding.

Results: Lymph nodes (6/13, 46%) were the most common metastatic sites, followed by the lung (4/13, 31%), liver (4/13, 31%), and the adrenal gland (2/13, 15%). The histologic variants including squamous (n = 1), micropapillary (n = 4), and plasmacytoid (n = 1) variants in five cases of UC. Most histologic variants (4/5, 80%) of primary UCs appeared in the metastatic lesions. In contrast, high-grade tumor budding was detected in six cases (46%), including one case of non-muscle invasive UC. Our study demonstrates that histologic variants are not uncommonly detected in distant metastatic UCs. Most histologic variants seen in primary UCs persist in the distant metastatic lesions. In addition, high-grade tumor budding, which occurs frequently in primary tumors, may contribute to the development of distant metastasis.

Conclusions: Therefore, assessing the presence or absence of histologic variants and tumor budding in UCs of the urinary bladder, even in non-muscle invasive UCs, may be useful to predict distant metastasis.

키워드

Bladder neoplasms; Distant metastasis; Urothelial carcinoma; Histologic variant; Tumor budding

원문 및 링크아웃 정보

등재저널 정보