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Effects of Oxygen Saturation Fluctuations on Retinopathy in Infants Younger than 30 Weeks’ Gestational Age

Neonatal Medicine 2021년 28권 1호 p.7 ~ 13
전채우, 김지수, 박범희, 이장훈,
소속 상세정보
전채우 ( Jeon Chae-Woo ) - Ajou University School of Medicine Department of Pediatrics
김지수 ( Kim Ji-Su ) - Ajou University Medical Center Ajou Research Institute for Innovative Medicine Office of Biostatistics
박범희 ( Park Bum-Hee ) - Ajou University Medical Center Ajou Research Institute for Innovative Medicine Office of Biostatistics
이장훈 ( Lee Jang-Hoon ) - Ajou University School of Medicine Department of Pediatrics

Abstract


Purpose: To evaluate the risk factors and effects of fluctuations in oxygen saturation on the occurrence and severity of retinopathy of prematurity (ROP).

Methods: From January 1, 2013 to January 31, 2020, 260 patients hospitalized in the neonatal intensive care unit of Ajou University Hospital were retrospectively analyzed.

Results: Sixty-six patients (25%) were diagnosed with ROP; of them 39 required treatment. In the multivariate regression analysis of ROP severity, the odds ratio (OR) of gestational age was 0.32 (95% confidence interval [CI], 0.22 to 0.47; P<0.0001). The OR of saturation of peripheral oxygen (SpO2) fluctuations at the 4th week after birth was 1.02 (95% CI, 1.02 to 1.12; P=0.041).

Conclusion: SpO2 fluctuations in premature infants younger than 30 weeks’ gestational age affects ROP severity, especially at the 4th week of life.

키워드

Retinopathy of prematurity; Risk factors; Oxygen

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