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Clinical Characteristics of Chronic Cough in Korea

Tuberculosis and Respiratory Diseases 2020년 83권 1호 p.31 ~ 41
안태준 ( An Tai-Joon ) - Catholic University College of Medicine Yeouido St. Mary’s Hospital Department of Internal Medicine

김진우 ( Kim Jin-Woo ) - Catholic University College of Medicine Uijeongbu St. Mary’s Hospital Department of Internal Medicine
최은영 ( Choi Eun-Young ) - Yeungnam University Hospital Department of Internal Medicine
장성훈 ( Jang Seung-Hun ) - Hallym University College of Medicine Hallym University Sacred Heart Hospital Department of Medicine
이화영 ( Lee Hwa-Young ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
강혜선 ( Kang Hye-Seon ) - Catholic University College of Medicine Bucheon St. Mary’s Hospital Department of Internal Medicine
 ( Koo Hyeon-Kyoung ) - Inje University College of Medicine Ilsan Paik Hospital Department of Internal Medicine
이종민 ( Lee Jong-Min ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
 ( Kim Sung-Kyung ) - Catholic University College of Medicine St. Vincent’s Hospital Department of Internal Medicine
신종욱 ( Shin Jong-Wook ) - Chung-Ang University College of Medicine Department of Internal Medicine
박소영 ( Park So-Young ) - Chungnam University Medical Center Division of Pulmonary and Critical Care Medicine
이진국 ( Rhee Chin-Kook ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Internal Medicine
문지용 ( Moon Ji-Yong ) - Hanyang University College of Medicine Hanyang University Guri Hospital Department of Internal Medicine
김이형 ( Kim Yee-Hyung ) - Kyung Hee University Hospital at Gangdong Department of Pulmonary and Critical Care Medicine
 ( Lee Hyun ) - Hanyang University College of Medicine Department of Internal Medicine
김용현 ( Kim Yong-Hyun ) - Catholic University College of Medicine Bucheon St. Mary’s Hospital Department of Internal Medicine
김제형 ( Kim Je-Hyeong ) - Korea University Ansan Hospital Department of Internal Medicine
이상학 ( Lee Sang-Haak ) - Catholic University College of Medicine St. Paul’s Hospital Department of Internal Medicine
김덕겸 ( Kim Deog-Kyeom ) - Seoul National University College of Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical Center Department of Internal Medicine Division of Pulmonary and Critical Care Medicine
김순종 ( Yoo Kwang-Ha ) - Konkuk University School of Medicine Department of Internal Medicine
김동규 ( Kim Dong-Gyu ) - Hallym University Kangnam Sacred Heart Hospital Department of Internal Medicine
정기석 ( Jung Ki-Suck ) - Hallym University College of Medicine Hallym University Sacred Heart Hospital Department of Medicine
김휘정 ( Kim Hui-Jung ) - Wonkwang University School of Medicine Wonkwang University Sanbon Hospital Department of Internal Medicine Division of Pulmonary and Critical Care Medicine
윤형규 ( Yoon Hyoung-Kyu ) - Catholic University College of Medicine Yeouido St. Mary’s Hospital Department of Internal Medicine

Abstract


Background: Chronic cough is defined as a cough lasting more than 8 weeks and socio-economic burden of chronic cough is enormous. The characteristics of chronic cough in Korea are not well understood. The Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) published guidelines on cough management in 2014. The current study evaluated the clinical characteristics of chronic cough in Korea and the efficacy of the KATRD guidelines.

Methods: This was a multi-center, retrospective observational study conducted in Korea. The participants were over 18 years of age. They had coughs lasting more than 8 weeks. Subjects with current pulmonary diseases, smokers, ex-smokers with more than 10 pack-years or who quit within the past 1 year, pregnant women, and users of cough-inducing medications were excluded. Evaluation and management of cough followed the KATRD cough-management guidelines.

Results: Participants with chronic cough in Korea showed age in the late forties and cough duration of more than 1 year. Upper airway cough syndrome was the most common cause of cough, followed by cough-variant asthma (CVA). Gastro-esophageal reflux diseases and eosinophilic bronchitis were less frequently observed. Following the KATRD cough-management guidelines, 91.2% of the subjects improved after 4 weeks of treatment. Responders were younger, had a longer duration of cough, and an initial impression of CVA. In univariate and multivariate analyses, an initial impression of CVA was the only factor related to better treatment response.

Conclusion: The causes of chronic cough in Korea differed from those reported in other countries. The current Korean guidelines proved efficient for treating Korean patients with chronic cough.

키워드

Cough; Cohort Studies; Epidemiology; Guideline; Diagnosis; Disease Management
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