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Circulating Tumor Cell Number Is Associated with Primary Tumor Volume in Patients with Lung Adenocarcinoma

Tuberculosis and Respiratory Diseases 2020년 83권 1호 p.61 ~ 70
강병주, 나승원, 이규상, Lim So-Yeoun, Son So-Hee, 안종준, Kim Byung-Chul,
소속 상세정보
강병주 ( Kang Byung-Ju ) - University of Ulsan College of Medicine Ulsan University Hospital Department of Internal Medicine
나승원 ( Ra Seung-Won ) - University of Ulsan College of Medicine Ulsan University Hospital Department of Internal Medicine
이규상 ( Lee Kyu-Sang ) - Clinomics Inc.
 ( Lim So-Yeoun ) - Ulsan University Hospital Department of Radiology
 ( Son So-Hee ) - Clinomics Inc.
안종준 ( Ahn Jong-Joon ) - University of Ulsan College of Medicine Ulsan University Hospital Department of Internal Medicine
 ( Kim Byung-Chul ) - Clinomics Inc.

Abstract


Background: Circulating tumor cells (CTCs) are frequently detected in patients with advanced-stage malignant tumors and could act as a predictor of poor prognosis. However, there is a paucity of data on the relationship between CTC number and primary tumor volume in patients with lung cancer. Therefore, our study aimed to evaluate the relationship between CTC number and primary tumor volume in patients with lung adenocarcinoma.

Methods: We collected blood samples from 21 patients with treatment-naive lung adenocarcinoma and 73 healthy individuals. To count CTCs, we used a CTC enrichment method based on fluid-assisted separation technology. We compared CTC numbers between lung adenocarcinoma patients and healthy individuals using propensity score matching, and performed linear regression analysis to analyze the relationship between CTC number and primary tumor volume in lung adenocarcinoma patients.

Results: CTC positivity was significantly more common in lung adenocarcinoma patients than in healthy individuals (p<0.001). The median primary tumor volume in CTC-negative and CTC-positive patients was 10.0 cm3 and 64.8 cm3, respectively. Multiple linear regression analysis showed that the number of CTCs correlated with primary tumor volume in lung adenocarcinoma patients (β=0.903, p=0.002). Further subgroup analysis showed a correlation between CTC number and primary tumor volume in patients with distant (p=0.024) and extra-thoracic (p=0.033) metastasis (not in patients with distant metastasis).

Conclusion: Our study showed that CTC numbers may be associated with primary tumor volume in lung adenocarcinomas patients, especially in those with distant metastasis.

키워드

Neoplastic Cells, Circulating; Tumor Burden; Adenocarcinoma of Lung

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