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An Overview of Genetic Information of Latent Mycobacterium tuberculosis

Tuberculosis and Respiratory Diseases 2021년 84권 1호 p.1 ~ 12
Hamidieh Faezeh, Farnia Parissa, Nowroozi Jamileh, Farnia Poopak, Velayati Ali Akbar,
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 ( Hamidieh Faezeh ) - Islamic Azad University Faculty of Biological Sciences Departement of Microbiology
 ( Farnia Parissa ) - Shahid Beheshti University of Medical Sciences National Research Institute of Tuberculosis and Lung Diseases Mycobacteriology Research
 ( Nowroozi Jamileh ) - Islamic Azad University Faculty of Biological Sciences Departement of Microbiology
 ( Farnia Poopak ) - Shahid Beheshti University of Medical Sciences National Research Institute of Tuberculosis and Lung Diseases Mycobacteriology Research
 ( Velayati Ali Akbar ) - Shahid Beheshti University of Medical Sciences National Research Institute of Tuberculosis and Lung Diseases Mycobacteriology Research

Abstract


Mycobacterium tuberculosis has infected more than two billion individuals worldwide, of whom 5%-10% have clinically active disease and 90%-95% remain in the latent stage with a reservoir of viable bacteria in the macrophages for extended periods of time. The tubercle bacilli at this stage are usually called dormant, non-viable, and/or non-culturable microorganisms. The patients with latent bacilli will not have clinical pictures and are not infectious. The infections in about 2%-23% of the patients with latent status become reactivated for various reasons such as cancer, human immunodeficiency virus infection, diabetes, and/or aging. Many studies have examined the mechanisms involved in the latent state of Mycobacterium and showed that latency modified the expression of many genes. Therefore, several mechanisms will change in this bacterium. Hence, this study aimed to briefly examine the genes involved in the latent state as well as the changes that are caused by Mycobacterium tuberculosis. The study also evaluated the relationship between the functions of these genes.

키워드

Mycobacterium tuberculosis; Latency; Tuberculosis; Dormancy; Hypoxic Conditions

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