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Effects of a Lifestyle-Modification Program on Blood-Glucose Regulation and Health Promotion in Diabetic Patients: A Randomized Controlled Trial

Journal of Lifestyle Medicine 2020년 10권 2호 p.77 ~ 91
신상욱, 정수진, 정은수, 황지현, 김우림, 소병옥, 박병현, 이승옥, 조백환, 박태선, 김영곤, 채수완,
소속 상세정보
신상욱 ( Shin Sang-Wook ) - Jeonbuk National University Department of Medical Nutrition Therapy
정수진 ( Jung Su-Jin ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods
정은수 ( Jung Eun-Soo ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods
황지현 ( Hwang Ji-Hyun ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods
김우림 ( Kim Woo-Rim ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods
소병옥 ( So Byung-Ok ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods
박병현 ( Park Byung-Hyun ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods
이승옥 ( Lee Seung-Ok ) - Chonbuk National University Medical School Department of Internal Medicine
조백환 ( Cho Baik-Hwan ) - Jinangun Medical Center
박태선 ( Park Tae-Sun ) - Chonbuk National University Medical School Department of Internal Medicine
김영곤 ( Kim Young-Gon ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods
채수완 ( Chae Soo-Wan ) - Chonbuk National University Hospital Clinical Trial Center for Functional Foods

Abstract


Background: We aimed to investigate the efficacy of the lifestyle intervention (LSI) program in controlling blood glucose regulation and health promotion in type 2 diabetic (T2D) patients.

Methods: Thirty adults with a diagnosed with diabetes were randomly assigned to LSI and control groups. The LSI group maintained their daily routines after participating twice in the LSI program, while control group maintained 4 weeks of daily life without participating in an intervention.

Results: HbA1c levels in the LSI group decreased significantly after participation (p = 0.025) compared with levels before the study, but there was no significant difference between the groups. The weight and body mass index (BMI) of the LSI group tended to decrease significantly compared with the control group (p = 0.054 and p = 0.055, respectively), and the waist circumference (WC) of the LSI group decreased significantly compared with that of the control group (p = 0.048). In the effects of the LSI program according to the polymorphism of GCKR genes, changes in glycated albumin (GA) (%), HbA1c, WC, BMI, and weight showed a significant decrease in the non-risk (TT genotype) GCKR group compared with the risk group (CC and TC genotype).

Conclusion: Application of the four-week LSI program to diabetics revealed positive effects on blood-glucose control and improvement in obesity indicators. In particular, the risk group with variations in the GCKR gene was associated with more genetic effects on indicators such as blood glucose and obesity than was the non-risk group.

키워드

Diabetic patients; Lifestyle modification; Personalized recommendation; Gene-based; Blood glucose; Direct-to-consumer test; Genotype; Health promotion

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