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Clinical and microbiological effects of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy: a pilot study

Journal of Periodontal & Implant Science 2021년 51권 1호 p.53 ~ 62
최은하, 엄흥식, 장범석, 이시영, 이재관,
소속 상세정보
최은하 ( Choi Eun-Ha ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology
엄흥식 ( Um Heung-Sik ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology
장범석 ( Chang Beom-Seok ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology
이시영 ( Lee Si-Young ) - Gangneung-Wonju National University College of Dentistry Department of Microbiology and Immunology
이재관 ( Lee Jae-Kwan ) - Gangneung-Wonju National University College of Dentistry Department of Periodontology

Abstract


Purpose: This study aimed to evaluate the clinical and microbiological efficacy of adjunctive local delivery of minocycline (Periocline®) in patients receiving supportive periodontal therapy (SPT) after initial treatment.

Methods: The participants were 16 men and 8 women (age, 20?65 years) who had at least 15 natural teeth, underwent SPT for more than 1 year due to chronic periodontitis, had 4 or more periodontal pocket sites deeper than 5 mm, and showed >25% gingival bleeding on probing (BoP). They were randomly assigned to the test and control groups. In the test group, mechanical debridement and local antibiotic delivery were performed for all periodontal sulci/pockets; in the control group, mechanical debridement and saline irrigation were performed. In patients who underwent SPT for more than 1 year, clinical and microbiological examinations were performed at baseline and 1 and 3 months after SPT. The clinical examination included an assessment of the periodontal pocket depth, clinical attachment level, plaque index, and BoP. Microbial tests were performed using real-time polymerase chain reaction; the relative ratios of Porphyromonas gingivalis and Fusobacterium nucleatum were determined.

Results: Both groups showed significant improvements in clinical parameters at 1 and 3 months from baseline; there were no significant changes between months 1 and 3. Intergroup differences were insignificant. The microbiological analysis revealed no significant differences in P. gingivalis and F. nucleatum ratios across time points. While intergroup differences were insignificant, there was a tendency for the P. gingivalis and F. nucleatum ratios to decrease in the test group.

Conclusions: Mechanical debridement in patients receiving maintenance therapy resulted in clinically significant improvement; the effectiveness of additional local delivery of antibiotics was not significant. The ratios of P. gingivalis and F. nucleatum showed a tendency to decrease in the test group, although it was not significant.

키워드

Chronic periodontitis; Drug delivery systems; Minocycline; Real-time polymerase chain reaction

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