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Hyperuricemia is Associated With an Increased Prevalence of Metabolic Syndrome in a General Population and a Decreased Prevalence of Diabetes in Men

Journal of Rheumatic Diseases 2020년 27권 4호 p.247 ~ 260
정혜민, 문지은, 전찬홍,
소속 상세정보
정혜민 ( Jeong Hye-Min ) - Soonchunhyang University Bucheon Hospital Division of Rheumatology
문지은 ( Moon Ji-Eun ) - Soonchunhyang University Bucheon Hospital Department of Biostatistics
전찬홍 ( Jeon Chan-Hong ) - Soonchunhyang University Bucheon Hospital Division of Rheumatology

Abstract


Objective: Elevated uric acid is associated with cardiovascular disease and metabolic syndrome. However, uric acid is also an antioxidant with beneficial effect on comorbidities. The aim of this study was to evaluate the relationship of serum uric acid with diabetes, metabolic syndrome, and cardiovascular disease in a Korean adult population.

Methods: A total of 5,887 (weighted n=40,251,868) participants aged ≥19 years from the 2016 Korean National Health and Nutrition Examination Survey were included for analysis. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed according to the presence of hyperuricemia and uric acid quartile.

Results: Participants of both sexes with hyperuricemia showed higher prevalence of metabolic syndrome, hypertension, hypertriglyceridemia, and obesity than those without hyperuricemia. After adjusting for socioeconomic and lifestyle characteristics, hyperuricemia was associated with a decreased prevalence of diabetes mellitus in men (OR: 0.44, 95% confidence interval [CI]: 0.28∼0.72, p=0.001) and a decreased prevalence of myocardial infarction or angina (OR: 0.25, 95% CI: 0.08∼0.75, p=0.013) in women. Hyperuricemia was significantly associated with an increased prevalence of metabolic syndrome in both men (OR: 1.81, 95% CI: 1.33∼2.45, p<0.001) and women (OR: 1.95, 95% CI: 1.22∼ 3.13, p=0.006).

Conclusion: Hyperuricemia was associated with a decreased prevalence of diabetes mellitus in men and a decreased prevalence of myocardial infarction or angina in women. Hyperuricemia was associated with an increased prevalence of metabolic syndrome in both men and women.

키워드

Uric acid; Metabolic syndrome; Diabetes mellitus

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