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Association Between Signal Transducers and Activators of Transcription 4 rs7574865 Polymorphism and Systemic Lupus Erythematosus: A Meta-analysis

Journal of Rheumatic Diseases 2020년 27권 4호 p.277 ~ 284
이영호, 송관규,
소속 상세정보
이영호 ( Lee Young-Ho ) - Korea University College of Medicine Department of Rheumatology
송관규 ( Song Gwan-Gyu ) - Korea University College of Medicine Department of Rheumatology

Abstract


Objective: The purpose of this study was to determine whether the rs7574865 polymorphism of signal transducers and transcription 4 activators (STAT4) in multiple ethnic populations is associated with susceptibility to systemic lupus erythematosus (SLE).

Methods: A meta-analysis on the STAT4 T allele rs7574865 polymorphism was performed in all subjects of study as well as in each ethnic population.

Results: It included twenty-four manuscripts with 36 comparative studies of 22,898 SLE patients and 24,838 controls. The mean frequency of the STAT4 rs7574865 T allele was 28.5%, ranging from 14.3% to 35.7%, among the controls. T allele rates were 14.3%, 22.8%, 31.9%, 32.4%, and 35.7%, respectively in African American, European, Arab, Asian, and Latin American populations. Meta-analysis revealed a substantial correlation in all subjects between STAT4 rs7574865 and SLE (odds ratio=1.549, 95% confidence interval=1.459∼1.644, p<0.001). Analysis after stratification of race showed a strong association between the STAT4 rs7574865 T allele and SLE in Europeans, Asians, Latin Americans, African Americans, and Arabs.

Conclusion: This meta-analysis demonstrated that the STAT4 rs7574865 polymorphism in different ethnic groups was correlated with SLE susceptibility, and that its prevalence depended on ethnicity.

키워드

STAT4 transcription factor; Genetic polymorphism; Systemic lupus erythematosus; Meta-analysis

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