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Canine Multicentric Large B Cell Lymphoma with Increased Mott Cells Diagnosed by Flow Cytometry

한국임상수의학회지 2021년 38권 1호 p.36 ~ 40
양예슬, 정재하, 황성현, 김용백,
소속 상세정보
양예슬 ( Yang Ye-Seul ) - Seoul National University College of Veterinary Medicine Laboratory of Clinical Pathology
정재하 ( Jung Jae-Ha ) - Seoul National University College of Veterinary Medicine Laboratory of Clinical Pathology
황성현 ( Hwang Sung-Hyun ) - Seoul National University College of Veterinary Medicine Laboratory of Clinical Pathology
김용백 ( Kim Yong-Baek ) - Seoul National University College of Veterinary Medicine Laboratory of Clinical Pathology

Abstract


A 12-year-old dog was referred due to multiple superficial lymphadenopathy. On cytology, each lymph node showed different cell populations where some of them consisted of intermediate to large lymphocytes with frequent Mott cells. Presence of Mott cells along with immature lymphocytes made the cytological diagnosis challenging, and therefore, supplementary diagnostic tests including PCR for Antigen Receptor Rearrangement (PARR) assay and flow cytometry were performed. This case report illustrates the value of flow cytometry in the diagnosis of lymphadenopathy with ambiguous cytologic findings.

키워드

flow cytometry; multicentric B cell lymphoma; Mott cells; immunophenotype; dog

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