잠시만 기다려 주세요. 로딩중입니다.

Co-evolving with Nature: The Recent Trends on the Mussel-inspired Polymers in Medical Adhesion

Biotechnology and Bioprocess Engineering 2021년 26권 1호 p.10 ~ 24
Basak Sayan,
소속 상세정보
 ( Basak Sayan ) - University of Calcutta Department of Polymer Science and Technology

Abstract


The rise in the number of daily surgical procedures and the disadvantages posed by the present surgical closure techniques (such as secondary tissue damage and microbial infection) magnifies the immediate need for metamorphosing the current bioadhesives perceiving to tether wounds efficiently. To this context, the emerging scope of biomimetics has allowed mussel inspired adhesives rendering efficient bonding characteristics on a variety of substrates. The mussel adhesion proteins and its derivatives, such as 3,4-dihydroxyphenylalanine and dopamine, are therefore widely being studied to modify the biopolymers, attempting to enhance the adhesive attributes. The polarity of the catechol groups in the protein conformation aids in the development of both noncovalent interactions (electrostatic interaction, hydrogen bonding, metal/ligand coordination bond, π-π/cation-π interactions) and covalent interactions (crosslinking), thereby promoting superior tissue adhesion. This narrative is an attempt to tether the recent developments in the mussel-inspired polymer adhesives, connecting the footprints of how these materials evolved with its current state of the art.

키워드

adhesives; adhesive polymers; biomaterials; biomimetic system; biopolymers; dopa; mussel foot proteins; wet adhesion

원문 및 링크아웃 정보

등재저널 정보