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Impressive effect of cisplatin monotherapy on a patient with heavily pretreated triple-negative breast cancer with poor performance

Yeungnam University Journal of Medicine 2020년 37권 3호 p.230 ~ 235
백동원, 박지영, 이수정, 채의수,
소속 상세정보
백동원 ( Baek Dong-Won ) - Kyungpook National University School of Medicine Kyungpook National University Chilgok Hospital Department of Oncology/Hematology
박지영 ( Park Ji-Young ) - Kyungpook National University School of Medicine Kyungpook National University Chilgok Hospital Department of Pathology
이수정 ( Lee Soo-Jung ) - Kyungpook National University School of Medicine Kyungpook National University Chilgok Hospital Department of Oncology/Hematology
채의수 ( Chae Yee-Soo ) - Kyungpook National University School of Medicine Kyungpook National University Chilgok Hospital Department of Oncology/Hematology

Abstract


Systemic therapy for metastatic triple-negative breast cancer (TNBC) still remains challenging because there are no targeted agents or endocrine therapies currently available. The present case report documents the successful use of cisplatin monotherapy to manage a heavily pretreated TNBC patient showing poor response to therapy. The patient was a 51-year-old woman who had already undergone several lines of systemic chemotherapy for widespread TNBC. Although the mutation analysis performed on DNA isolated from blood cells and progressed lesion samples confirmed the tumor to be germline BRCA wild-type, cisplatin monotherapy was administered based on the increasing evidence of safety and efficacy of platinum for breast cancer. After three cycles of cisplatin treatment, the patient’s metastatic lesions dramatically improved without any major toxicity, and she completed 17 cycles with good response. This case study indicates that patients with heavily pretreated TNBC can potentially achieve a good response to cisplatin monotherapy.

키워드

Antineoplastic agents; Cisplatin; DNA repair; Triple negative breast neoplasms

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