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Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population

Annals of Laboratory Medicine 2021년 41권 1호 p.77 ~ 85
Zou Yutong, Wang Danchen, Cheng Xinqi, Ma Chaochao, Lin Songbai, Hu Yingying, Yu Songlin, Xia Liangyu, Li Honglei, Yin Yicong, Liu Huaicheng, Zhang Dianxi, Zhang Kui, Lian Xiaolan, Xu Tengda, Qiu Ling,
소속 상세정보
 ( Zou Yutong ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Wang Danchen ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Cheng Xinqi ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Ma Chaochao ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Lin Songbai ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Health Care
 ( Hu Yingying ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Yu Songlin ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Xia Liangyu ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Li Honglei ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Yin Yicong ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Liu Huaicheng ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Zhang Dianxi ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Zhang Kui ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory
 ( Lian Xiaolan ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Endocrinology
 ( Xu Tengda ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Health Care
 ( Qiu Ling ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Clinical Laboratory

Abstract


Background: Thyroid diseases are highly prevalent worldwide, but their diagnosis remains a challenge. We established reference intervals (RIs) for thyroid-associated hormones and evaluated the prevalence of thyroid diseases in China.

Methods: After excluding outliers based on the results of ultrasound screening, thyroid antibody tests, and the Tukey method, the medical records of 20,303 euthyroid adults, who visited the Department of Health Care at Peking Union Medical College Hospital from January 2014 to December 2018, were analyzed. Thyroid-associated hormones were measured by the Siemens Advia Centaur XP analyzer. The RIs for thyroid-associated hormones were calculated according to the CLSI C28-A3 guidelines, and were compared with the RIs provided by Siemens. The prevalence of thyroid diseases over the five years was evaluated and compared using the chi-square test.

Results: The RIs for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), and total triiodothyronine (TT3) were 0.71?4.92 mIU/L, 12.2?20.1 pmol/L, 3.9?6.0 pmol/L, 65.6?135.1 nmol/L, and 1.2?2.2 nmol/L, respectively. The RIs of all hormones except TT4 differed significantly between males and females. The RIs of TSH increased with increasing age. The prevalence of overt hypothyroidism, overt hyperthyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism was 0.5% and 0.8%, 0.2% and 0.6%, 3.8% and 6.1%, and 3.3% and 4.7% in males and females, respectively, which differed from those provided by Siemens.

Conclusions: Sex-specific RIs were established for thyroid-associated hormones, and the prevalence of thyroid diseases was determined in the Chinese population.

키워드

Thyroid-associated hormones; Reference interval; Hyperthyroidism; hypothyroidism; Prevalence

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